Hybrid 99m Tc-magnetite tracer for dual modality sentinel lymph node mapping

Journal of Materials Science. Materials in Medicine
A CousinsBenjamin Thierry

Abstract

Accuracy of sentinel lymph node identification using radioactive tracers in non-superficial cancers can be limited by radiation shine through and low spatial resolution of detection systems such as intraoperative gamma probes. By utilising a dual radioactive/magnetic tracer, sensitive lymphoscintigraphy can be paired with high spatial resolution intraoperative magnetometer probes to improve the accuracy of sentinel node detection in cancers with complex multidirectional lymphatic drainage. Dextran-coated magnetite nanoparticles (33 nm mean hydrodynamic diameter) were labelled with 99mTc and applied as a lymphotropic tracer in small and large animal models. The dual tracer could be radiolabelled with 98 ± 2% efficiency after 10 min of incubation at room temperature. Biodistribution studies of the tracer were conducted in normal rats (subdermal and intravenous tail delivery, n = 3) and swine (subdermal hind limb delivery, n = 5). In rats the dual tracer migrated through four tiers of lymph node, 20 min after subdermal injection. Results from intravenous biodistribution test for radiocolloids demonstrated no aggregation in vivo, however indicated the presence of some lower-molecular weight radioactive impurities (99mTc-dextran). I...Continue Reading

References

Mar 24, 1998·Journal of the American College of Surgeons·P J BorgsteinS Meijer
Apr 13, 1999·European Journal of Nuclear Medicine·R A Valdés OlmosB B Kroon
Aug 4, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C van de VenT Lerut
Feb 3, 2000·Seminars in Nuclear Medicine·P Zanzonico, S Heller
Aug 6, 2000·European Journal of Radiology·M F BellinS Precetti-Morel
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Taku NakagawaJun-ichi Ogawa
Mar 15, 2005·Seminars in Nuclear Medicine·John N Aarsvold, Naomi P Alazraki
Apr 12, 2005·Nuclear Medicine and Biology·Kazuhisa MatsunagaYoshiharu Karube
Oct 13, 2005·European Journal of Nuclear Medicine and Molecular Imaging·H LermanE Even-Sapir
Apr 25, 2007·Annals of Surgical Oncology·Stephan GretschelPeter M Schlag
Jan 23, 2010·Biomaterials·Jin XieXiaoyuan Chen
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthias NahrendorfRalph Weissleder
Feb 11, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Renata MadruSven-Erik Strand
Apr 25, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Nynke S van den BergFijs W B van Leeuwen
Jan 24, 2013·Current Topics in Medicinal Chemistry·Penelope BouziotisCharalampos Tsoukalas
Sep 3, 2013·Current Medicinal Chemistry·G Ferro-FloresE Azorín-Vega
Dec 11, 2013·Annals of Surgical Oncology·Michael DouekUNKNOWN SentiMAG Trialists Group
Feb 25, 2015·International Journal of Nanomedicine·Joost J PouwBennie Ten Haken
May 23, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Piñero-MadronaUNKNOWN Grupo de Estudios Senológicos de la Sociedad Española de Patologia Mamaria (SESPM)

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