Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

Current Medicinal Chemistry
Aysegul HanikogluTomris Ozben

Abstract

Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative st...Continue Reading

References

Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Sep 19, 2003·Molecular Biotechnology·Uwe Trefzer, Peter Walden
Oct 22, 2004·Nutrition Journal·Michael S Donaldson
Oct 4, 2006·Nature Reviews. Drug Discovery·Scott WilhelmSusan Kelley
Dec 8, 2006·The Biochemical Journal·Barry Halliwell
Aug 2, 2007·Accounts of Chemical Research·Bernard Meunier
Aug 9, 2008·Drug Discovery Today·De-Xin KongHong-Yu Zhang
Jan 31, 2009·Nature Reviews. Drug Discovery·Jia JiaYu Zong Chen
Feb 18, 2009·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Changfeng WuJason McNeill
Mar 10, 2009·Genes & Development·Russell G Jones, Craig B Thompson
May 30, 2009·Nature Reviews. Drug Discovery·Dunyaporn TrachoothamPeng Huang
Dec 25, 2010·Drug News & Perspectives·Shikha S ChauhanPrem M S Chauhan
Mar 15, 2011·Drug Development Research·Francis W Muregi, Akira Ishih
Dec 22, 2011·Journal of Medicinal Chemistry·Helen HagenAndriy Mokhir
May 9, 2012·Journal of Physiology and Biochemistry·Aysegul CortTomris Ozben
Aug 14, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Kuen-Daw TsaiJaw-Ming Cherng
Sep 25, 2012·Journal of Physiology and Biochemistry·Aysegul CortTomris Ozben
Jan 22, 2013·European Journal of Medicinal Chemistry·Asif HusainRavinesh Mishra
May 8, 2013·Expert Opinion on Drug Discovery·Sébastien Fortin, Gervais Bérubé
May 25, 2013·Current Pharmaceutical Design·Lisa Dalla ViaAntonio Toninello
May 28, 2013·Antioxidants & Redox Signaling·Delira Robbins, Yunfeng Zhao
Jun 12, 2013·Acta orthopaedica et traumatologica turcica·Hakan ÖzbenTomris Özben
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Rakesh Kumar Gupta, Neeta Singh
Dec 3, 2014·European Journal of Medicinal Chemistry·Violeta MarkovićMilan D Joksović
Dec 3, 2014·European Journal of Medicinal Chemistry·Ke-Guang ChengZhen-Feng Chen
Dec 17, 2014·European Journal of Medicinal Chemistry·Wagdy M EldehnaHatem A Abdel-Aziz
Dec 17, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marie-Hélène TeitenMarc Diederich
Jan 3, 2015·European Journal of Medicinal Chemistry·Jing Bo ShiXin Hua Liu
Feb 7, 2015·Bioorganic & Medicinal Chemistry Letters·Li-Ying MaHong-Min Liu
Feb 11, 2015·Anti-cancer Agents in Medicinal Chemistry·Ferhat HanikogluTomris Ozben
Mar 21, 2015·Bioorganic & Medicinal Chemistry·Prinka SinglaKamaldeep Paul

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Citations

Mar 11, 2020·Biomolecules·Piotr WójcikElżbieta Skrzydlewska
May 6, 2020·Current Medicinal Chemistry·Luciano SasoTamas Csont
Jun 19, 2019·Oxidative Medicine and Cellular Longevity·Enza VernucciMatteo A Russo
May 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir N KoshelevLudmila V Ivanova

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