Hybrid Fe3O4-Poly(acrylic acid) Nanogels for Theranostic Cancer Treatment

Journal of Biomedical Nanotechnology
Ying ChenZhen Gu

Abstract

Multifunctional nanomedicine integrated with both therapy and diagnostics holds vast potential in cancer treatment. We developed hybrid Fe3O4-poly(acrylic acid) (PAA) nanogels for both drug delivery and magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 nanoparticles were encapsulated inside porous PAA nanogels via an in situ co-precipitation approach. With successive growth of magnetic nanoparticles, the highest magnetization saturation (M(s)) value of the Fe3O4 nanoparticles in the PAA nanogels was determined as 20 emu/g. The resulting hybrid Fe3O4-PAA nanogels showed high drug loading capacity (98%) and sustained drug release in vitro. Cytotoxicity assays and cellular imaging demonstrated that the hybrid nanogels were highly biocompatible and efficiently internalized in human neuroblastoma SH-SY5Y cells. In MRI studies, the hybrid nanogels exhibited an excellent contrast in T2 weighted imaging and a high MRI sensitivity in the tumor site.

Citations

Dec 23, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Weixin HouEdward Kai-Hua Chow
Aug 21, 2019·Anti-cancer Agents in Medicinal Chemistry·Paromita KunduSanjeeb K Sahoo
Jul 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ying LinXiqun Jiang
Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Kebede K KefeniBhekie B Mamba
Sep 1, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marzieh MohammadiMona Alibolandi
Nov 14, 2020·Journal of Nanoscience and Nanotechnology·Shanying WuXiangbin Kong

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