Hybrid Mesoporous-Microporous Nanocarriers for Overcoming Multidrug Resistance by Sequential Drug Delivery

Molecular Pharmaceutics
Liucan WangKaiyong Cai

Abstract

Combination chemotherapy with a modulator and a chemotherapeutic drug has become one of the most promising strategies for the treatment of multidrug resistance (MDR) in cancer therapy. However, the development of nanocarriers with a high payload and sequential release of therapeutic agents poses a significant challenge. In this work, we report a type of hybrid nanocarriers prepared by polydopamine (PDA) mediated integration of the mesoporous MSN core and the microporous zeolite imidazolate frameworks-8 (ZIF-8) shell. The nanocarriers exploit storage capacities for drugs based on the high porosity and molecular sieving capabilities of ZIF-8 for sequential drug release. Particularly, large amounts of an anticancer drug (DOX, 607 μg mg-1) and a MDR inhibitor curcumin (CUR, 778 μg mg-1) were sequentially loaded in the mesoporous core via π-π stacking interactions mediated by PDA and in the microporous shell via the encapsulation during ZIF-8 growth. The sustained release of DOX was observed to follow earlier and faster release of CUR by acid-sensitive dissolution of the ZIF-8 shell. Furthermore, the nanoparticles showed good biocompatibility and effective cellular uptake in in vitro evaluations using drug-resistant MCF-7/ADR cancer...Continue Reading

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Citations

Apr 25, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Menghuan LiKaiyong Cai
Oct 29, 2018·Journal of Nanobiotechnology·Ji-Jun FuCheng-Cheng Liu
Jan 18, 2020·Angewandte Chemie·Isabel Abánades LázaroRoss S Forgan
Oct 17, 2019·Biomaterials Science·Kaiyao SunJessica M Rosenholm
Sep 19, 2020·Advanced Healthcare Materials·Genhua LiuKaiyong Cai
Feb 25, 2020·Inorganic Chemistry·Roya Karimi Alavijeh, Kamran Akhbari
Aug 29, 2021·Pharmaceutics·Giovanna C N B LôboSônia N Báo
Nov 18, 2021·Advanced Healthcare Materials·He DingPiaoping Yang
Aug 14, 2020·Nano Today·Sepideh AhmadiMichael R Hamblin

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