Hybrid Nanoreactors: Enabling an Off-the-Shelf Strategy for Concurrently Enhanced Chemo-immunotherapy

Angewandte Chemie
Yannan YangChengzhong Yu

Abstract

Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for amplifying the immunogenic cell death and activating immune cells. A simple physical mixture of nanoreactors and chemodrugs in combination with immune checkpoint blockades show synergistically and concurrently enhanced chemo-immunotherapy efficacy, inhibiting the growth of both treated primary immunosuppressive tumors and untreated distant tumors. The off-the-shelf strategy uses tumor antigens generated in situ and avoids cargo loading, and is thus a substantial advance in personalized nanomedicine for clinical translation.

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Citations

Jul 23, 2019·Advanced Materials·Bowen YangJianlin Shi
Apr 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei Feng, Yu Chen
Aug 14, 2020·Advanced Healthcare Materials·Shuren WangYanglong Hou
Sep 29, 2020·Biomaterials Science·Chuanchuan HeGuangya Xiang
Feb 6, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Weiqi WangHaijun Yu
Sep 17, 2019·Biomaterials Science·Junjie ZhangLianhui Wang
Nov 4, 2020·Biomaterials Science·Jiahui PeiXiao-Dong Zhang
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Nov 12, 2020·Advanced Science·Caihong DongJianqiao Zhou
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May 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wangwei ZhuXueting Ye
May 25, 2021·Chemical Society Reviews·Yuxuan XiongXiangliang Yang
Oct 29, 2019·ACS Applied Materials & Interfaces·Jing ZhangYuxia Luan
Aug 22, 2020·Journal of the American Chemical Society·Lisen LinXiaoyuan Chen
Mar 6, 2019·ACS Nano·Weijing YangXiaoyuan Chen
Apr 12, 2019·Chemical Reviews·Bowen YangJianlin Shi
Jul 16, 2020·Accounts of Chemical Research·Yannan YangChengzhong Yu
Oct 2, 2021·Advanced Materials·Yang LiuHongjie Zhang
Oct 30, 2021·Chemical Communications : Chem Comm·Yanhua LiBo Tang
Jan 26, 2022·Journal of the American Chemical Society·He MaXiaojun Peng

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