Hybrid peripheral nerve sheath tumors: report of five cases and detailed review of literature

BMC Cancer
Nasir Ud DinRashida Ahmed

Abstract

Hybrid peripheral nerve sheath tumors (PNSTs) have been recognized recently and were first included in the 4th edition of World Health Organization (WHO) Classification of Tumors of Soft tissue and Bone, published in 2013. These tumors show combined features of more than one type of conventional benign peripheral nerve sheath tumors. The most common combinations are those of schwannoma/perineurioma followed by combinations of neurofibroma/schwannoma and neurofibroma/perineurioma. A detailed literature review of published cases is presented. We have discussed the types and etiology, epidemiology and sites of localization, gross and microscopic appearances and immunohistochemical features of hybrid PNSTs and association of these tumors with tumor syndromes. We have included five cases which were diagnosed in our department as we believe that publication of these new cases is relevant for the improved understanding of these specific tumors. Four of our five patients were males, mean age was 24 years. There was wide variation in the location of these tumors. Mean size of excised tumors was 5.5 cms in the greatest dimensions. Three out of five cases represented hybrid schwannoma/perineurioma histologically. No significant nuclear at...Continue Reading

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Citations

Jan 25, 2020·The American Journal of Dermatopathology·Koorosh HaghayeghiLeslie Robinson-Bostom
Mar 12, 2019·Ophthalmic Plastic and Reconstructive Surgery·Louis J StevensonThomas G Hardy
Jan 2, 2020·Surgical Neurology International·Sukwoo Hong, Takayuki Hara
Oct 6, 2020·Veterinary Pathology·Lisa G LaniganBrad Bolon

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Methods Mentioned

BETA
surgical resection

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