Abstract
Following an acute coronary syndrome, combined CT and PET with 18F-NaF can identify coronary atherosclerotic plaques that have ruptured or eroded. However, the processes behind 18F-NaF uptake in vulnerable plaques remain unclear. Ten patients with STEMI were scanned after 18F-NaF injection, for 75 minutes in a Siemens PET/MR scanner using delayed enhancement (LGE). They were then scanned in a Siemens PET/CT scanner for 10 minutes. Tissue-to-background ratio (TBR) was compared between the culprit lesion in the IRA and remote non-culprit lesions in an effort to independently validate prior studies. Additionally, we performed a proof-of-principle study comparing TBR in scar tissue and remote myocardium using LGE images and PET/MR or PET/CT data. From the 33 coronary lesions detected on PET/CT, TBRs for culprit lesions were higher than for non-culprit lesions (TBR = 2.11 ± 0.45 vs 1.46 ± 0.48; P < 0.001). Interestingly, the TBR measured on the PET/CT was higher for infarcted myocardium than for remote myocardium (TBR = 0.81 ± 0.10 vs 0.71 ± 0.05; P = 0.003). These results were confirmed using the PET/MR data (TBR = 0.81 ± 0.10 for scar, TBR = 0.71 ± 0.06 for healthy myocardium, P = 0.03). We confirmed the potential of 18F-NaF PET/C...Continue Reading
References
Jun 1, 1970·American Journal of Clinical Pathology·A N D'Agostino, M Chiga
Mar 1, 1996·Medical Image Analysis·W M WellsR Kikinis
Mar 4, 2000·Heart·M J Davies
Feb 27, 2001·Circulation·H HuangR T Lee
Oct 5, 2001·Current Opinion in Cardiology·F D KolodgieR Virmani
Aug 15, 2002·Circulation·G RioufolA Tabib
Sep 13, 2002·Journal of the American College of Cardiology·Akiko MaeharaNeil J Weissman
Oct 15, 2003·Circulation·Morteza NaghaviJames T Willerson
Sep 11, 2004·Journal of the American College of Cardiology·Elliott M AntmanUNKNOWN Canadian Cardiovascular Society
Sep 24, 2005·Physics in Medicine and Biology·Maurizio ContiVladimir Panin
Nov 5, 2005·Scandinavian Cardiovascular Journal : SCJ·Einar HeibergHåkan Arheden
Jul 11, 2006·IEEE Transactions on Medical Imaging·Vladimir Y PaninMichael Casey
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuliya VengrenyukSheldon Weinbaum
Jun 20, 2008·Vascular Health and Risk Management·Matthew J Budoff, Khawar M Gul
Jan 13, 2010·BMC Medical Imaging·Einar HeibergHåkan Arheden
Nov 18, 2011·Circulation·Marc Richard DweckDavid E Newby
Feb 24, 2012·AJR. American Journal of Roentgenology·Jabi E ShrikiAlison Wilcox
Apr 21, 2012·Journal of the American College of Cardiology·Marc R DweckDavid E Newby
May 3, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Jeanette Schulz-MengerEike Nagel
Sep 3, 2013·Journal of Graduate Medical Education·Gail M Sullivan, Richard Feinn
Nov 15, 2013·Lancet·Nikhil V JoshiDavid E Newby
Apr 26, 2014·Future Cardiology·Rachel K DongworthDerek J Hausenloy
Oct 5, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jeong Hee HanWon Woo Lee
Jan 21, 2015·Journal of the American College of Cardiology·Armin Arbab-Zadeh, Valentin Fuster
Jul 8, 2015·Nature Communications·Agnese IrkleAnthony P Davenport
Oct 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mathieu RubeauxPiotr J Slomka
Citations
Jan 19, 2018·Basic Research in Cardiology·Daniel CurleyRené M Botnar
Jan 19, 2019·Journal of Clinical Medicine·Rosalinda MadonnaRaffaele De Caterina
Jun 25, 2019·Cardiovascular Research·Mark G MacAskillAdriana A S Tavares
Oct 9, 2019·Current Opinion in Lipidology·Suraj Dahal, Matthew J Budoff
Feb 6, 2020·The British Journal of Radiology·Osamu ManabeNagara Tamaki
Apr 3, 2020·The British Journal of Radiology·Nicholas R EvansJames Hf Rudd
Sep 2, 2020·European Radiology·Koosha PaydaryAbass Alavi
Jul 12, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jamie W BellingeCarl J Schultz
Aug 8, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Beatriz Isabel Silva MendesMaria João Vidigal Ferreira
Dec 1, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Daniele MasseraPiotr J Slomka
Nov 28, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Poul F Høilund-CarlsenOke Gerke
Jan 4, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Jacek KwiecinskiPiotr J Slomka
Feb 23, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Claudia Calcagno, Zahi A Fayad
Jun 20, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mercy I AkereleCharalampos Tsoumpas
Jul 12, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Abass AlaviPoul Flemming Høilund-Carlsen
Feb 22, 2021·European Journal of Preventive Cardiology·Alexandru FloreaFelix M Mottaghy
Nov 9, 2020·PET Clinics·Poul Flemming Høilund-CarlsenAbass Alavi
Mar 23, 2021·Molecular Imaging·Jacek KwiecinskiPiotr J Slomka
Jan 22, 2019·European Journal of Hybrid Imaging·C RischplerF Nensa
Jul 2, 2021·Current Cardiology Reports·Andrej ĆorovićJason M Tarkin
Aug 23, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Honest NdlovuMike Sathekge
Aug 28, 2021·Diagnostics·Babak SabouryPoul Flemming Høilund-Carlsen