PMID: 9548201Apr 21, 1998Paper

Hybrid phantoms for testing the measurement of regional dynamics in dynamic renal scintigraphy

Nuclear Medicine Communications
M Sámal, H Bergmann

Abstract

A hybrid phantom is a synthetic dynamic scintigraphic study reconstructed from dynamic components of real clinical data. The aim of a hybrid simulation is to provide realistic reference studies with systematically varying quantitative diagnostic parameters for testing the quality of measurement of regional dynamics. The components of the phantom are extracted from a representative patient study using factor analysis. Prior to the construction of the phantom, selected components are modified in a known way or substituted with heterologous data. The phantom study is constituted from the altered components using a procedure inverse to factor analysis, and completed by the addition of residual noise. The hybrid phantom is a compromise between simulated and software phantoms. Unlike simulated phantoms, it preserves a significant part of data variability and the natural complex structure of scintigraphic images. Unlike software phantoms, it provides values for selected diagnostic parameters or magnitudes of their relative changes. A set of hybrid phantoms from a dynamic renal study and the results of a pilot clinical evaluation are presented.

Citations

Aug 16, 2001·Nuclear Medicine Communications·J O HeikkinenP J Rautio
Oct 7, 2008·Nuclear Medicine Communications·Cyril C NimmonMartin Sámal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.