Hybrid scaffold composed of hydrogel/3D-framework and its application as a dopamine delivery system

Journal of Controlled Release : Official Journal of the Controlled Release Society
Kyung Shin KangDong-Woo Cho

Abstract

Cell-based drug delivery systems (DDSs) have been increasingly exploited because cells can be utilized as a continuous drug delivering system to produce therapeutic molecules over a more extended period compared to the simple drug carriers. Although hydrogels have many advantages for this application, their mechanical properties are generally not desirable to structurally protect implanted cells. Here, we present a three-dimensional (3D) hybrid scaffold with a combination of a 3D framework and a hydrogel to enhance the mechanical properties without chemically altering the transport properties of the hydrogel. Based on the 3D Ormocomp scaffold (framework) fabricated by projection-based microstereolithography with defined parameters, we developed a 3D hybrid scaffold by injection of the mixture of cells and the alginate gel into the internal space of the framework. This hybrid scaffold showed the improved mechanical strength and the framework in the scaffold played the role of an adhesion site for the encapsulated cells during the culture period. Additionally, we confirmed its protection of exogenous human cells from acute immune rejection in a mouse model. Eventually, we demonstrated the feasibility of applying this hybrid scaff...Continue Reading

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Citations

Feb 9, 2016·Soft Matter·S MotamedM I Aguilar
Apr 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sytze J BuwaldaWim E Hennink
Dec 15, 2015·Maturitas·C Rodríguez-NogalesM J Blanco-Prieto
Mar 1, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ju Young ParkDong-Woo Cho
Nov 25, 2017·Advanced Healthcare Materials·Hwan D KimNathaniel S Hwang
May 9, 2019·Artificial Organs·Alireza Dehqan NiriBasil Mujokoro
Dec 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ju Young ParkDong-Woo Cho
Sep 28, 2017·Bioengineering·Hee-Gyeong YiDong-Woo Cho
Dec 18, 2019·Current Opinion in Chemical Engineering·Luisa L PalmeseKristi L Kiick

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