Hybrid Theranostic Platform for Second Near-IR Window Light Triggered Selective Two-Photon Imaging and Photothermal Killing of Targeted Melanoma Cells

ACS Applied Materials & Interfaces
Christine TchounwouParesh Chandra Ray

Abstract

Despite advances in the medical field, even in the 21st century cancer is one of the leading causes of death for men and women in the world. Since the second near-infrared (NIR) biological window light between 950 and 1350 nm offers highly efficient tissue penetration, the current article reports the development of hybrid theranostic platform using anti-GD2 antibody attached gold nanoparticle (GNP) conjugated, single-wall carbon nanotube (SWCNT) for second near-IR light triggered selective imaging and efficient photothermal therapy of human melanoma cancer cell. Reported results demonstrate that due to strong plasmon-coupling, two-photon luminescence (TPL) intensity from theranostic GNP attached SWCNT materials is 6 orders of magnitude higher than GNP or SWCNT alone. Experimental and FDTD simulation data indicate that the huge enhancement of TPL intensity is mainly due to strong resonance enhancement coupled with the stronger electric field enhancement. Due to plasmon coupling, the theranostic material serves as a local nanoantennae to enhance the photothermal capability via strong optical energy absorption. Reported data show that theranostic SWCNT can be used for selective two-photon imaging of melanoma UACC903 cell using 110...Continue Reading

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Citations

May 18, 2016·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Sudarson Sekhar SinhaParesh Chandra Ray
Jan 18, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Stacy JonesParesh Chandra Ray
Mar 7, 2017·Biochemistry. Biokhimii︠a︡·L A Dykman, N G Khlebtsov
Jan 28, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Salman BagheriHamid Kooshki
Feb 6, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rachel S Riley, Emily S Day
Aug 11, 2018·Journal of Cancer Research and Clinical Oncology·Harshita MishraSushama Talegaonkar
Jul 26, 2017·Chemistry, an Asian Journal·Peng Zheng, Nianqiang Wu
Feb 23, 2021·Frontiers in Chemistry·Xiao-Guang GaoFei Xing
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ganeshlenin Kandasamy, Dipak Maity
Dec 21, 2016·Accounts of Chemical Research·Sudarson Sekhar SinhaParesh Chandra Ray
Dec 11, 2017·ACS Biomaterials Science & Engineering·Hui GaoYi Hu
Sep 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K R Sneha, G S Sailaja

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