Feb 1, 1976

Hybrid-versus-parental strain reaction. III. Comparative mortality in parental strain mice of the H-2k genotype

Journal of the National Cancer Institute
D E Uphoff


Lethally irradiated parental strain male and female mice were inoculated with marrow from reciprocal hybrid donors of the same sex. Hybrid cells homozygous for the H-2k genotype could recognize the quantitatively greater antigenicity of the parental strain CBA male recipients only. The more severe reaction occurred when the maternal strain of the hybrid donor was allogeneic to the recipient, which indicates the maternal effect on the antigen recognition system. This demonstration of a maternal influence on the expression of paternally derived tissue antigens made it possible to attribute the secondary disease syndrome to a hybrid-versus-parental strain reaction. The apparent differences in mortality between male and female recipients could not be attributable to X or Y chromosome disparity without additional transfers of appropriate marrow from males to females and females to males. In all cases, the parental strain-versus-hybrid reaction resulted in greater mortality than that observed in the hybrid-versus-parental strain reaction.

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Mentioned in this Paper

Mice, Inbred CBA
Hybridization, Intraspecies
Graft Vs Host Reaction
Secondary Parkinson Disease
Transplantation, Homologous
Bone Marrow Cell Transplantation
Bone Marrow Cells
Mice, Inbred AKR

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