PMID: 6985745DOI: 10.1126/science.6985745Jan 4, 1980Paper
Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite
Science
N YoshidaM Aikawa
Abstract
Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.
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Mar 8, 2010·Socrates Herrera Valencia
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