Hybrids of ravuconazole: synthesis and biological evaluation

European Journal of Medicinal Chemistry
Nitin D GaikwadVivek D Bobade

Abstract

In continuation of our work on antimicrobial agents, a number of hybrid molecules 4a-y containing thiazole and triazole pharmacophores were designed and synthesized. The structure of the compounds was established by IR, NMR, MS and CHN analysis. All the synthesized compounds were tested for qualitative (Zone of inhibition) and quantitative (MIC) antimicrobial activities against four pathogenic bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa and two pathogenic fungi Candida albicans and Aspergillus niger. Of all the synthesized compounds screened, most of them show potent antimicrobial activity against Gram positive and Gram negative bacteria as well as the fungi species.

Citations

Sep 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina NastasăOvidiu Oniga
Oct 9, 2014·European Journal of Medicinal Chemistry·I BriguglioA Carta
Jan 8, 2013·Expert Opinion on Therapeutic Patents·Vitor F FerreiraJorge L Magalhães
Jan 13, 2016·Molecular Diversity·Fateme Ghanbari Pirbasti, Nosrat O Mahmoodi
Jul 7, 2019·European Journal of Medicinal Chemistry·Jitendra NalawadePravin C Mhaske
Feb 12, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Luana da S M ForeziVitor F Ferreira

Related Concepts

BMS-207147
Microbicides
Aspergillus niger
Candida albicans
Fungus Drug Sensitivity Tests
Thiazoles
Triazoles
Organic Synthesis
Antibiotics
Aspergillus niger

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