Hydralazine-associated Amenorrhea in a Premenopausal Patient With Chronic Kidney Disease: A Case Report and Review of Literature

Clinical Therapeutics
Kwadwo A YeboahBrian M Shepler

Abstract

Several antihypertensive medications have been associated with various forms of sexual dysfunction. We present a case report of a premenopausal patient with hydralazine-associated amenorrhea. The Naranjo adverse drug reaction probability scale was used to assess causality. We also performed a literature search on PubMed to find publications that report hydralazine-associated amenorrhea. The Naranjo scale generated a score of 6, suggesting a probable relationship between amenorrhea and hydralazine therapy. No publications associating hydralazine with amenorrhea were identified. A probable relationship exists between hydralazine and the development of amenorrhea.

Citations

Mar 1, 2019·Journal of Medical Economics·Bruce SpinowitzHolly B Krasa

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