Hydrated sodium calcium aluminosilicate (HSCAS), acidic HSCAS, and activated charcoal reduce urinary excretion of aflatoxin M1 in turkey poults. Lack of effect by activated charcoal on aflatoxicosis

Toxicology Letters
T S EdringtonT D Phillips

Abstract

In one experiment, the effect of inorganic sorbents on the metabolic fate of aflatoxin B1 (AFB1) was studied in turkey poults. At 5 weeks of age, female poults were surgically colostomized and 9 days later orally dosed with 0.75 mg AFB1/kg BW. Hydrated sodium calcium aluminosilicate (HSCAS), acidic HSCAS, and activated charcoal (AC) were tested, by concomitant administration with AFB1. Urine was collected up to 48 h post-dosing and analyzed for aflatoxin M1 (AFM1) which was the major metabolite found in all treatment groups. Hydrated sodium calcium aluminosilicate, previously proven beneficial in alleviating aflatoxicosis in farm animals, reduced urinary AFM1 output when orally dosed simultaneous with AFB1. Also, acidic HSCAS and AC significantly decreased AFM1 excretion when administered concomitantly with AFB1. A second experiment was conducted to evaluate the ability of two types of AC to modify aflatoxicosis when added to aflatoxin (AF)-contaminated (from culture material) diets of turkey poults. Although AC was able to decrease AFM1 excretion in the first experiment, no protective effects from AF toxicity were observed in the feeding study.

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Citations

Jul 6, 2001·Toxicology Letters·A HuwigH Dutler
Nov 10, 2006·Critical Reviews in Food Science and Nutrition·Bulent KabakIşil Var
Jul 21, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·G JardA Lebrihi
Mar 7, 2003·Journal of the American Veterinary Medical Association·Allen K BinghamJohn E Bauer
Dec 10, 2013·Journal of the Science of Food and Agriculture·Erika D WomackDarrell L Sparks
Feb 18, 2010·Acta Veterinaria Hungarica·Miklós MézesKatalin Tóth
May 10, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·María Del Pilar MongeStella Maris Chiacchiera
Dec 24, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Hong PengGuangtao Zhang
Sep 10, 2020·Critical Reviews in Food Science and Nutrition·P F Cuevas-GonzálezH S García
Apr 25, 2018·Journal of Dairy Science·I M OgunadeA T Adesogan
Aug 10, 2019·PeerJ·Hans-Peter SchmidtClaudia Kammann
Feb 1, 2019·Clays and Clay Minerals·Timothy D PhillipsJia-Sheng Wang
Apr 1, 2010·Journal of Agricultural and Food Chemistry·Lauren E SeifertTimothy H Sanders

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