Hydration of nucleosides in dilute aqueous solutions. Ultrasonic velocity and density measurements.

Biophysical Chemistry
V A BuckinR L Kazaryan

Abstract

The values of the concentration increments of the ultrasound velocity and their temperature slopes, apparent molar volumes, apparent molar expansibilities, apparent molar adiabatic compressibilities and their temperature gradients for 12 nucleosides and their analogs, as well as for ribose and deoxyribose, have been obtained using precision measurements of ultrasound velocity and density. The following hydration parameters for the atomic groups of the nucleosides, reflecting the state of water in the hydration shells of these groups, have been analyzed: (1) the contribution of ribose to the values of the concentration increment of ultrasound velocity A, the apparent molar volumes phi v and apparent molar adiabatic compressibilities phi ks of nucleosides; (2) contributions of the CH3, NH2 and O = ... -H groups of nucleic bases to the A, phi v and phi ks values of nucleosides and free nucleic bases; (3) contributions of the 2'-OH group of ribose to the values of A, phi v and phi ks nucleosides; (4) changes in the A values of nucleosides and free nucleic bases upon their protonation and deprotonation. Data have been obtained on the mutual influence of the atomic groups of nucleosides on their hydration. It is shown that the GC pai...Continue Reading

Citations

Aug 1, 1994·Biophysical Chemistry·T V ChalikianK J Breslauer
Jul 2, 2010·The Journal of Chemical Physics·P Glancy, W P Beyermann
Mar 10, 2011·Analytical Biochemistry·Pablo Resa, Vitaly Buckin
Mar 4, 2000·Biopolymers·T V Chalikian, K J Breslauer
Mar 16, 2019·The Journal of Physical Chemistry. B·Yuelong Li, Vitaly Buckin
Nov 1, 2001·Journal of the American Chemical Society·B I Kankia, L A Marky

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