Hydration of the dienic lipid dioctadecadienoylphosphatidylcholine in the lamellar phase--an infrared linear dichroism and x-ray study on headgroup orientation, water ordering, and bilayer dimensions

Biophysical Journal
H BinderG Klose

Abstract

In the phospholipid 1,2-bis(2,4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (DODPC) in each of the fatty acid chains, a rigid diene group is inserted in a position near the polar/apolar boundary that is exceptionally sensitive for membrane stability. DODPC transforms upon gradual dehydration from the liquid-crystalline to a metastable gel state, which rearranges into two subgel phases at low and intermediate degrees of hydration. The molecular dimensions of the respective bilayers were determined by means of x-ray diffraction. Infrared linear dichroism of selected vibrations of the phosphate and trimethylammonium groups and of the nu13(OH) band of water adsorbed onto the lipid was used to study the molecular order in the polar part of the bilayers in macroscopically oriented samples. The dense packing of the tilted acyl chains in the subgel causes the in-plane orientation of the phosphatidylcholine headgroups with direct interactions between the phosphate and trimethylammonium groups, and a strong orientation of adsorbed water molecules. In the more disordered gel, the thickness of the polar part of the bilayer increases and the lateral interactions between the lipid headgroups weaken. The higher order in the headgroup regi...Continue Reading

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Citations

Nov 8, 2006·European Biophysics Journal : EBJ·Hans Binder
Jun 6, 2002·Chemistry and Physics of Lipids·Hans Binder, Olaf Zschörnig
Apr 26, 2001·Biophysical Chemistry·H BinderO Zschörnig
Sep 12, 2000·Current Opinion in Structural Biology·T J McIntosh
Jun 4, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Eric E RossSteven R Bugni
Nov 27, 2015·The Journal of Physical Chemistry. B·Alexey A Dmitriev, Nikolay Vladimirovich Surovtsev
Jul 6, 2010·Chemistry and Physics of Lipids·Masanao KinoshitaSatoru Kato
Oct 16, 2015·The Journal of Physical Chemistry. a·Arkadiusz MatwijczukMariusz Gagoś
Dec 19, 2000·The Journal of Biological Chemistry·S ChoosakoonkriangC R Middaugh
Sep 19, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Daniela PozziGiulio Caracciolo
Aug 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Giulio CaraccioloRuggero Caminiti
Jan 9, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·E A Disalvo, M A Frias
Feb 28, 2007·Biophysical Journal·Takeshi FukumaSuzanne P Jarvis
Jul 20, 2006·Journal of the American Chemical Society·Victor V VolkovRoberto Righini

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