Hydraulic conductivity of polymer matrices.

Biophysical Chemistry
W D Comper, O Zamparo

Abstract

We demonstrate that the chondroitin sulfate proteoglycan exhibits enhanced sensitivity to the flow of water compared to other macromolecules which is in accord with their functional role in conferring compressive resistance to cartilage. In order to understand factors that may contribute to its low hydraulic conductivity, a comparative study of hydraulic conductivity, as measured by the sedimentation velocity technique is made of various macromolecules representing variations in charge density, chemical composition, thermodynamic nonideality, size and flexibility. The polymers examined were dextran, poly(ethylene glycol), poly(vinyl alcohol), albumin, and dextran sulfate. The differences in hydraulic conductivity between the various macromolecules could not be explained by conventional theories which included prediction of hydraulic conductivity related to the radius of the molecule regarded as a uniform cylinder, nor the absolute charge density of the molecule and nor to the steric hindrance offered by the macromolecule to the diffusion of tritiated water. A qualitative relationship is established, however, between the noncounterion polymer contribution to osmotic activity and the resistance to water flow for polymers with hig...Continue Reading

References

Oct 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J R Levick
Jul 3, 1973·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J D Wells
Oct 1, 1968·The International Journal of Applied Radiation and Isotopes·B W Fox
Oct 1, 1968·The Biochemical Journal·E Edmond, A G Ogston

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Citations

May 1, 1995·Annals of the Rheumatic Diseases·J R Levick, J N McDonald
Jan 3, 2013·Journal of Biomedical Materials Research. Part a·Keith H K WongJoe Tien
Jun 2, 2009·Biomaterials·James G TruslowJoe Tien
Aug 15, 1990·Biophysical Chemistry·R P Williams, W D Comper

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