Hydride transfer versus hydrogen radical transfer in thymidylate synthase.

Journal of the American Chemical Society
Baoyu HongAmnon Kohen

Abstract

The nature of a H-transfer in the thymidylate synthase catalyzed reaction was investigated by comparison of the wild-type enzyme with the W80M mutant. The nature of the H-transfer was not affected, as indicated by intrinsic isotope effects and their temperature dependence. These findings support a single-step hydride transfer instead of a two-step radical transfer.

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Citations

Dec 8, 2011·Journal of Chemical Information and Modeling·Jing ShiYao Fu
Jun 26, 2010·Journal of the American Chemical Society·Zhen Wang, Amnon Kohen
Oct 5, 2012·Journal of the American Chemical Society·Zhen WangAmnon Kohen
Nov 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anand Minajigi, Christopher S Francklyn
Apr 12, 2011·Journal of the American Chemical Society·Natalia KanaanVicent Moliner
May 16, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel RostonAmnon Kohen
Apr 12, 2008·The International Journal of Biochemistry & Cell Biology·Aldo A Arvizu-FloresRogerio R Sotelo-Mundo
May 23, 2015·Chemical Communications : Chem Comm·Palwinder SinghAmrinder Singh
Mar 18, 2008·Chembiochem : a European Journal of Chemical Biology·Sanuele CalòMaria Paola Costi
Sep 12, 2018·The Journal of Physical Chemistry. a·Sadegh Salehzadeh, Farahnaz Maleki
Jun 21, 2014·Journal of the American Chemical Society·Zahidul IslamAmnon Kohen
Jul 5, 2012·The Journal of Organic Chemistry·Xiaozhen HanVernon D Parker

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