Hydrocephalus in achondroplasia: the possible role of intracranial venous hypertension

Journal of Neurosurgery
P SteinbokO Flodmark

Abstract

The significance and cause of ventriculomegaly in achondroplasia was investigated in five achondroplastic children. The intraventricular pressure (IVP) was monitored over 24 hours, followed by intraventricular injection of radionuclide alone or in combination with water-soluble contrast material. The IVP was elevated and the reabsorption of cerebrospinal fluid (CSF) into the sagittal sinus was slow in all cases, but there was no obstruction to CSF flow. The spinal subarachnoid space was well seen in all patients. Jugular venograms with pressure monitoring were obtained in four patients (bilaterally in one). These studies confirmed a narrow jugular foramen in all patients with a significant venous pressure gradient (3 to 10 mm Hg) obtained while the catheter was being pulled back from the sigmoid sinus through the foramen. A second gradient was found in the jugular vein in two patients at the level of the upper thoracic aperture. This gradient was 6 and 14 mm Hg, respectively. Identical venograms and monitoring of the venous pressure in a control group showed no pressure gradients across the jugular foramen and smaller gradients (2 to 5 mm Hg) across the thoracic inlet. It is concluded from these studies that ventriculomegaly in...Continue Reading

References

Sep 1, 1978·The Journal of Pediatrics·W A HortonJ G Hall
May 1, 1975·Journal of Neurosurgery·F L Haar, C A Miller
Oct 1, 1975·Journal of Pediatric Surgery·D R StewartG G Myers
Apr 1, 1975·Developmental Medicine and Child Neurology·J C DepresseuxA Stevenaert
Feb 1, 1985·American Journal of Medical Genetics·J T HechtRichard M Pauli
Jul 1, 1971·Neuropädiatrie·B L WiseS Kaufman
Sep 1, 1967·The Journal of Pediatrics·M E CohenD D Matson
Nov 1, 1969·Journal of Neurosurgery·H NorrellV Bertan
Aug 1, 1965·Journal of Neurosurgery·K SHULMAN, J RANSOHOFF
May 1, 1967·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·L O LangerR J Gorlin
Apr 1, 1984·Journal of Neurosurgery·Christian Sainte-RoseJ F Hirsch
Jan 1, 1982·Brain & Development·X R Wu, K F Swaiman
Jun 1, 1980·Journal of Computer Assisted Tomography·E R HeinzP J Dubois
Jul 1, 1980·Neurology·S M Mueller, J E Reinertson
Aug 1, 1980·Neurosurgery·W A Friedman, J P Mickle
Jan 1, 1981·Journal of Neurosurgery·H YamadaN Kageyama
Aug 1, 1956·Archives of Disease in Childhood·J L EMERY, R B ZACHARY
Jun 1, 1959·A.M.A. Archives of Neurology and Psychiatry·E A BERING, B SALIBI
Sep 1, 1961·Brain : a Journal of Neurology·J P DENNISE C ALVORD
Jun 1, 1964·Archives of Neurology·K SHULMANJ RANSOHOFF
Mar 1, 1962·Journal of Neurosurgery·M E KINAL
Jul 1, 1946·Journal of Neurosurgery·D J K BECK, D S RUSSELL

Citations

Apr 19, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R D Hayward
May 6, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Giuseppe CinalliDominique Renier
May 3, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H CollmannJ Krauss
Sep 11, 1998·Journal of Medical Genetics·A G HunterC I Scott
Jan 1, 1993·The Journal of Pediatric Endocrinology·T YamateY Seino
Oct 3, 2009·Journal of Neurosurgery. Pediatrics·James A J KingJames T Rutka
Oct 3, 2009·Journal of Neurosurgery. Pediatrics·A H Menezes
Jan 3, 2012·Journal of Neurosurgery. Pediatrics·Dale M SwiftBrian Robertson
Jul 1, 1994·Journal of Neurosurgery·T C Ryken, A H Menezes
Jun 1, 1995·Journal of Neurosurgery·D N ThompsonB M Jones
Dec 25, 2007·Journal of Neurosurgery·H L Rekate
Apr 1, 2006·Journal of Neurosurgery·Carlos A BagleyB Carson
Mar 18, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ronald B J GlassThomas P Naidich
Oct 18, 2014·Journal of Neurosurgery. Pediatrics·William W ScottDale M Swift
Apr 13, 2000·Brain & Development·N Gordon
Sep 24, 2015·American Journal of Medical Genetics. Part a·Klane K WhiteRavi Savarirayan
Jul 17, 2007·Lancet·W A HortonJ T Hecht
Oct 1, 2010·The Saudi Dental Journal·Afnan Al-Saleem, Asma Al-Jobair
Sep 25, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Thangamadhan BosemaniAndrea Poretti
Sep 9, 2016·American Journal of Medical Genetics. Part a·Kimberley WiggMelanie Porter
May 17, 2013·Veterinary Pathology·K D SipmaW Back
Mar 3, 1997·American Journal of Medical Genetics·R S Lachman
Oct 21, 1998·American Journal of Medical Genetics·H SuzumuraG Nishimura
Apr 17, 1999·American Journal of Medical Genetics·N M ThompsonJ M Fletcher
Nov 15, 2007·American Journal of Medical Genetics. Part a·Robert L ConwayJohn M Graham
Oct 2, 2008·Plastic and Reconstructive Surgery·Damian D MarucciR D Hayward
Feb 27, 2010·The Journal of Craniofacial Surgery·Adrianna RangerDamir Matic
Jul 25, 2000·Journal of Neurosurgical Anesthesiology·I ElmaciO Hurko
Nov 9, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Smruti K PatelFrancesco T Mangano
Jun 23, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H L Rekate
Jan 5, 2019·Orphanet Journal of Rare Diseases·Richard M Pauli
Jan 1, 1994·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·S A SaponaroS Mandel
Feb 23, 2017·Current Osteoporosis Reports·Sheila UngerElvire Gouze
Mar 17, 2017·Annual Review of Genomics and Human Genetics·Judith G Hall
Jun 4, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H L Rekate
Feb 14, 2021·Orphanet Journal of Rare Diseases·Youngbo ShimJi Hoon Phi
Nov 3, 2020·Pediatric Radiology·Fatma Ceren SariogluHandan Guleryuz

Related Concepts

Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans
Cerebrovascular Occlusion
Aqueductal Stenosis
Hypertensive Disease
Structure of Jugular Vein
Venography - Procedure
Venous Blood Pressure
Cerebral Ventriculography

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.