Hydrochlorothiazide and Indapamide bind the NADPH binding site of bacterial Dihydrofolate Reductase: results of an in-silico study and their implications.

In Silico Pharmacology
Sumanpreet KaurDibyajyoti Banerjee

Abstract

Hypertension is a public health concern. Low dose thiazide diuretics are known to effectively control blood pressure compared to that of other classes of antihypertensive drugs. In this context, we have performed an in-silico study and found that the two Sulphonamide Diuretics Hydrochlorothiazide and Indapamide bound the NADPH binding region of bacterial Dihydrofolate Reductase. Therefore, akin to Sulphonamide Antibiotics, Sulphonamide Diuretics may have antibiotic activity and thereby have the potential to modulate the gut microbiome in a way beneficial to vascular health. The in-silico experiment results were analyzed in the context of the relevant literature. We postulate that Sulphonamide Diuretics exert their antihypertensive role by modulating the gut microbiome, specifically by increasing butyrate-producing taxa in the gut. We recommend extending such work as it is plausible that Indapamide and other Sulphonamide Diuretics may be beneficial for both diabetes and hypertension.

References

Aug 5, 1978·British Medical Journal·D S ReevesD W Bullock
Apr 1, 1992·Journal of Clinical Pharmacy and Therapeutics·K Landin-Wilhelmsen
May 3, 2002·Journal of Human Hypertension·E Escobar
Jul 25, 2003·American Journal of Hypertension·Shi-Wen KuoWei-Cheng Lian
Apr 15, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Munemichi InabaShigehiro Katayama
Jun 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·M G WulffeléC D A Stehouwer
Apr 29, 2009·Journal of Computational Chemistry·Garrett M MorrisArthur J Olson
May 5, 2011·Journal of Computational Chemistry·Vincent ZoeteOlivier Michielin
Dec 23, 2011·Journal of Hypertension·Hisatomi ArimaJohn Chalmers
Apr 15, 2015·Hypertension·Tao YangMansour Mohamadzadeh
Aug 25, 2015·International Journal of Cardiology·YanFei QiCarl J Pepine
Apr 7, 2016·American Journal of Hypertension·George C Roush, Domenic A Sica
Dec 13, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kunal ManiarDibyajyoti Banerjee
Dec 25, 2016·Physiological Genomics·Sareema AdnanDavid J Durgan
Mar 21, 2017·Current Hypertension Reports·Jennifer L Pluznick
Aug 3, 2017·Biochemistry·Scott A GabelRobert E London
Jan 8, 2019·Diabetes, Obesity & Metabolism·Malcolm J BorgTongzhi Wu
Feb 6, 2019·Hormones : International Journal of Endocrinology and Metabolism·Natalia G VallianouStylianos Tsagarakis

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Multimode Reader
Xmgrace
AUTODOCK
GROMACS
Poseview
Chemspace
SwissParam
Pymol

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

British Medical Journal
D M DUNLOP
Canadian Journal of Comparative Medicine and Veterinary Science
R A McIntosh
Canadian Journal of Comparative Medicine and Veterinary Science
© 2021 Meta ULC. All rights reserved