Hydrocortisone down-regulates the tumor suppressor gene BRCA1 in mammary cells: a possible molecular link between stress and breast cancer

Genes, Chromosomes & Cancer
Lilia Antonova, Christopher R Mueller

Abstract

Psychological stress has been correlated with breast cancer development in numerous epidemiological studies. However, physiological and molecular models which may account for this association are not readily available. We have found that the stress hormone hydrocortisone (cortisol) down-regulates the expression of the breast cancer susceptibility gene BRCA1 in the nonmalignant mouse mammary cell line EPH4. This effect is concentration-dependent, is reliant on the continuous presence of hydrocortisone, and is not affected by the addition of lactogenic hormones, or growth conditions. Hydrocortisone was also found to negate a known positive effect of estrogen on BRCA1 expression and, therefore, may interfere with estrogen-related signaling in mammary epithelial cells. The repressive effect of hydrocortisone is diminished or lost in the mouse mammary lines HC-11 and SP1, respectively, suggesting regulation of the BRCA1 may differ between lines. We have uncovered two promoter regulatory sites, which are involved in BRCA1 regulation by hydrocortisone, namely the RIBS and UP regulatory elements. Binding of the transcription factor GABP to both sites is lost upon hydrocortisone addition, though the levels of these factors are not alter...Continue Reading

References

Nov 1, 1985·Psychiatry Research·R GlaserJ E Holliday
Feb 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y Taketani, T Oka
Jul 1, 1974·The Journal of Investigative Dermatology·J C Porter
Oct 6, 1995·The Journal of Biological Chemistry·A G RosmarinC P Simkevich
Apr 10, 1995·American Journal of Medical Genetics·M J SellerG S Tint
Feb 1, 1996·The International Journal of Neuroscience·H K FischmanD D Kelly
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·J V RajanL A Chodosh
Jul 9, 1998·Molecular Carcinogenesis·D RomagnoloC A Afshari
May 18, 1999·Biochemical and Biophysical Research Communications·D A FavyD J Bernard-Gallon
Feb 24, 2001·Journal of Behavioral Medicine·L CohenQ Wei
Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·K LillbergM Koskenvuo
Apr 27, 2001·Neuroscience and Biobehavioral Reviews·S M Korte
Sep 6, 2001·Oncogene·D N DiNardoD I Rodenhiser
Jun 1, 2002·Molecular and Cellular Endocrinology·Abraham Amsterdam, Ravid Sasson
Feb 1, 2003·Breast Cancer Research : BCR·Christopher R Mueller, Calvin D Roskelley
Mar 5, 2003·Brain, Behavior, and Immunity·Eric V Yang, Ronald Glaser
Mar 5, 2003·American Journal of Epidemiology·Kirsi LillbergMarkku Koskenvuo
May 27, 2003·Journal of Cellular Physiology·Eliot M RosenItzhak D Goldberg
Jun 6, 2003·Current Opinion in Cell Biology·Lea M Starita, Jeffrey D Parvin
Sep 27, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·O HelgessonL Lissner
Oct 8, 2003·Patient Education and Counseling·E M Bleiker, H M van der Ploeg
Nov 6, 2003·International Journal of Cancer. Journal International Du Cancer·Saskia F A DuijtsBart Vd Borne
Jun 17, 2004·Molecular and Cellular Biology·Mahnaz RazandiEllis R Levin
Oct 19, 2004·Biochimica Et Biophysica Acta·Onard J L M SchoneveldWouter H Lamers
Mar 24, 2005·Journal of Cellular and Molecular Medicine·R G Dumitrescu, I Cotarla

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Citations

Oct 30, 2013·Breast Cancer Research and Treatment·Myriam VilascoUNKNOWN BRACAPS
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gretchen L HermesMartha K McClintock
Apr 15, 2010·The Journal of Clinical Investigation·Penney M GilbertValerie M Weaver
May 18, 2011·Breast Cancer Research : BCR·Lilia AntonovaChristopher R Mueller
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan K LutgendorfMichael H Antoni
Jul 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan K LutgendorfAnil K Sood
Jul 19, 2012·Clinical Epidemiology·Paul J Fitzgerald
Oct 25, 2011·Psychosomatic Medicine·Susan K Lutgendorf, Anil K Sood
Dec 3, 2014·The Psychiatric Clinics of North America·Frances Figueroa-Fankhanel
Apr 11, 2014·International Review of Psychiatry·Ingrid Barrera, David Spiegel
Dec 24, 2015·European Journal of Medicinal Chemistry·Bhowmira RathoreRajkumar Banerjee
Mar 23, 2012·Psycho-oncology·David Spiegel
Apr 12, 2013·Arthritis and Rheumatism·Trevor E DavisGeorge C Tsokos
Aug 29, 2013·British Journal of Health Psychology·David Spiegel
Jul 14, 2012·Brain, Behavior, and Immunity·N D PowellJ F Sheridan
Jun 1, 2016·IUBMB Life·Jean-Pierre ObeidJimmy El Hokayem
Jun 18, 2016·Breast Cancer Research and Treatment·Jamie M ZeitzerDavid Spiegel
Dec 26, 2017·Clinical Nursing Research·Fatmeh Ahmad AlzoubiYazeed Mohammad Gougazeh
Jan 27, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jennifer Taylor VenerisGini F Fleming
Sep 27, 2018·Breast Cancer Research and Treatment·Timothy M BarrowHyang-Min Byun
Nov 26, 2016·Cancer Immunology, Immunotherapy : CII·Yuri L BunimovichMichael R Shurin
Feb 14, 2012·Molecular Cancer Research : MCR·Heather D RitterChristopher R Mueller

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