Apr 28, 2009

Hydrodynamic selection of the kinetic pathway of a polymer coil-globule transition

Physical Review Letters
Kumiko KamataHajime Tanaka


Recently, the role of hydrodynamic interactions in the selection of a kinetic pathway for phase transitions has attracted considerable attention. Here we study this problem numerically by taking as an example a coil-globule transition of a single polymer, which is a prototype model of protein folding. When a swollen polymer collapses into a globule state, hydrodynamic interactions accelerate the transition. We find, on the other hand, that when a rather compact polymer collapses into the same final state, hydrodynamic interactions decelerate the transition due to a slow squeezing process of the solvent. We reveal that the degree of the initial enhancement of anisotropy of the polymer configuration determines whether hydrodynamic interactions accelerate or decelerate the collapsing dynamics. We also discuss the possible relevance of squeezing flow effects in protein folding.

  • References8
  • Citations15


Mentioned in this Paper

Biochemical Pathway
COIL gene
Protein Folding, Globular
Protein Folding

About this Paper

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

The European Physical Journal. E, Soft Matter
N KikuchiJ M Yeomans
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Masahiro Fujita, Yukio Yamaguchi
Physical Review Letters
M RipollM P Lettinga
© 2020 Meta ULC. All rights reserved