Hydrodynamic simulation of multicellular embryo invagination

Physical Biology
Philippe-Alexandre Pouille, Emmanuel Farge

Abstract

The mechanical aspects of embryonic morphogenesis have been widely analysed by numerical simulations of invagination in sea urchins and Drosophila gastrulation. Finite element models, which describe the tissue as a continuous medium, lead to the global invagination morphogenesis observed in vivo. Here we develop a simulation of multicellular embryo invagination that allows access to both cellular and multicellular mechanical behaviours of the embryo. In this model, the tissue is composed of adhesive individual cells, in which shape change dynamics is governed by internal acto-myosin forces and the hydrodynamic flow associated with membrane movements. We investigated the minimal structural and force elements sufficient to phenocopy mesoderm invagination. The minimal structures are cell membranes characterized by an acto-myosin cortical tension and connected by apical and basal junctions and an acto-myosin contractile ring connected to the apical junctions. An increase in the apical-cortical surface tension is the only control parameter change required to phenocopy most known multicellular and cellular shape changes of Drosophila gastrulation. Specifically, behaviours observed in vivo, including apical junction movements at the o...Continue Reading

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Citations

Sep 26, 2013·PloS One·Philipp Spahn, Rolf Reuter
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Edouard HannezoJean-Francois Joanny
Sep 13, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Russell P WolfeTabassum Ahsan
Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Matthew A WyczalkowskiLarry A Taber
Sep 26, 2015·Annual Review of Cell and Developmental Biology·Maria-Elena Fernandez-SanchezEmmanuel Farge
Jul 5, 2013·Biophysical Journal·Matteo RauziMaria Leptin
May 20, 2015·Development, Growth & Differentiation·Takefumi Kondo, Shigeo Hayashi
Apr 14, 2016·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Nimit DhulekarBulent Yener
Apr 14, 2016·Biophysical Journal·Mahim MisraStanislav Y Shvartsman
Sep 7, 2011·Current Opinion in Genetics & Development·Frank M Mason, Adam C Martin
Sep 27, 2012·Biophysical Journal·Ana Hočevar BrezavščekPrimož Ziherl
Aug 17, 2014·Developmental Biology·Alyssa J Manning, Stephen L Rogers
Jul 9, 2009·Nature Reviews. Genetics·Andrew C OatesCarl-Philipp Heisenberg
Oct 27, 2015·Nature Communications·Matteo RauziMaria Leptin
May 5, 2009·Physical Biology·Xiaoyan MaM Shane Hutson
Oct 6, 2011·Computer Methods in Biomechanics and Biomedical Engineering·R AllenaD Aubry
Jul 6, 2019·Nature Communications·Mélanie GraciaMagali Suzanne
Aug 18, 2020·Developmental Cell·Anastasiya TrushkoAurélien Roux
Jul 11, 2021·Cells & Development·Meritxell Font-NogueraMagali Suzanne
Aug 28, 2021·The Journal of Cell Biology·Sourabh BhideMaria Leptin
Apr 16, 2009·Science Signaling·Philippe-Alexandre PouilleEmmanuel Farge

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