Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain

Translational Stroke Research
Aswathi GopalakrishnanG K Rajanikant

Abstract

Chronic brain injury following cerebral ischemia is a severe debilitating neurological condition, where clinical intervention is well known to decrease morbidity and mortality. Despite the development of several therapeutic strategies, clinical outcome in the majority of patients could be better improved, since many still face life-long neurological deficits. Among the several strategic options that are currently being pursued, tissue engineering provides much promise for neural tissue salvage and regeneration in brain ischemia. Specifically, hydrogel biomaterials have been utilized to docket biomolecules, adhesion motifs, growth factors, and other proneural cues for stable stem cell encapsulation. Here, we provide an overview of therapeutic applications of hydrogels in stroke treatment. Special focus is given to design considerations for generation of efficient hydrogel systems for neurological applications. Therapeutic applications of hydrogels in stroke as conducive microenvironments for stem cell transplantation and drug delivery have been discussed. Finally, we present our perspectives on clinical translation of hydrogels for neural tissue regeneration.

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Citations

Jan 9, 2020·Journal of the Royal Society, Interface·Pallavi MadhusudananSahadev Shankarappa
Feb 23, 2020·CNS Neuroscience & Therapeutics·Zhi WangChao-Yu Miao
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Mikhail M MoisenovichDmitry B Zorov
Dec 8, 2020·Frontiers in Cellular Neuroscience·María Lacalle-AuriolesThomas M Durcan
Apr 6, 2021·Oxidative Medicine and Cellular Longevity·Guini SongYue He
Apr 24, 2021·International Journal of Biological Macromolecules·Isadora C CarvalhoZelia I P Lobato
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Guoyang ZhouLin Wang
Jan 16, 2022·Translational Stroke Research·Tong ZhaoJianhong Zhu
Feb 8, 2022·Cellular and Molecular Neurobiology·Qi-Song SuPing Zhu

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Methods Mentioned

BETA
bioprinting
biosensors
chemical exchange saturation transfer
light sheet microscopy

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

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