Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Polymers
Daniela AilincaiLuminita Marin

Abstract

This paper reports new formulations based on chitosan, citral, and diclofenac sodium salt (DCF). The central idea was to encapsulate an anionic drug into a polycationic hydrogel matrix in order to increase the intermolecular forces between them and thus to ensure slower drug release, while citral was used as a penetration enhancer to assure efficient delivery of the drug. Hydrogels without drug were also synthesized and used as a reference. The structure, morphology, and supramolecular architecture of the drug delivery systems were evaluated by FTIR spectroscopy, scanning electron microscopy, polarized optical microscopy, and wide-angle X-ray diffraction. The drug release kinetics was monitored in vitro by UV-VIS spectroscopy, in physiological conditions, while the enzymatic and hydrolytic degradability of the hydrogels were evaluated in the presence of lysozyme and phosphate buffer saline (PBS), at 37 °C. All of the data revealed that the anionic DCF was strongly anchored into the polycationic matrix and the drug was slowly released over 7 days. Moreover, the release rate can be controlled by simple variation of the molar ratio between the polycationic chitosan and lipophilic citral.

References

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Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Daniela AilincaiLuminita Marin
May 30, 2020·International Journal of Biological Macromolecules·Manuela-Maria IftimeLuminita Marin
Jul 1, 2020·International Journal of Biological Macromolecules·Daniela AilincaiLuminita Marin

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Citations

Jun 3, 2021·Animals : an Open Access Journal From MDPI·Andra Sabina Neculai-ValeanuŞteofil Creangă

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Methods Mentioned

BETA
X-ray
polarized
optical microscopy
atomic force microscopy
AFM

Software Mentioned

Image J

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