PMID: 26328444Sep 4, 2015Paper

Hydrogels Containing Nanocapsules and Nanoemulsions of Tea Tree Oil Provide Antiedematogenic Effect and Improved Skin Wound Healing

Journal of Nanoscience and Nanotechnology
F C FloresCristiane B da Silva

Abstract

In previous works, we developed nanocapsules and nanoemulsions containing the tea tree oil. The aim of this work was to prepare and characterize hydrogels containing these nanocarriers, and to evaluate their in vivo efficacy in protecting skin damage induced by UVB and cutaneous wound healing. Hydrogels were prepared using Carbopol Ultrez and their physicochemical characteristics were evaluated: macroscopic analysis, pH, spreadability and rheological properties. The in vivo antiedematogenic effect was evaluated by ear thickness measurement after UVB-irradiation. In order to evaluate healing action of hydrogels, we investigated the regression of the cutaneous lesion in rats. Hydrogels showed homogeneous aspect and pH values between 5.6-5.8 and a non-Newtonian behavior. The presence of nanocapsules and nanoemulsions in hydrogels did not change their spreadability profile. The inclusion of tea tree oil in the nanocapsules and nanoemulsions allowed reducing the edema induced by UVB exposure. Hydrogel containing nanocapsules presented a higher reduction of the wound area compared to the hydrogel containing nanoemulsions and hydrogel containing allantoin. This study shows the feasibility of obtained dermatological formulations contai...Continue Reading

Citations

Sep 15, 2020·Drug Delivery and Translational Research·Karoll Moangella Andrade de AssisBolívar Ponciano Goulart de Lima Damasceno
Jan 27, 2021·International Journal of Pharmaceutics·Ricardo LorenzoniSilvia Stanisçuaski Guterres
Feb 27, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Juliana Rizzo GnattaMaria Júlia Paes da Silva
Sep 2, 2020·Colloids and Surfaces. B, Biointerfaces·Patricia Inês BackHelder Ferreira Teixeira
May 1, 2021·Pharmaceutics·Thi Phuong Nga HoangBarbara R Conway
Dec 16, 2019·Journal of Ethnopharmacology·Gabriela BeckerSara Marchesan Oliveira

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