Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery.

Nanoscale Research Letters
Cristiane Rd HoffmeisterSílvia S Guterres

Abstract

The aim of the present study was to develop a transdermal system for controlled delivery of melatonin combining three strategies: nanoencapsulation of melatonin, drying of melatonin-loaded nanocapsules, and incorporation of nanocapsules in a hydrophilic gel. Nanocapsules were prepared by interfacial deposition of the polymer and were spray-dried using water-soluble excipients. In vitro drug release profiles were evaluated by the dialysis bag method, and skin permeation studies were carried out using Franz cells with porcine skin as the membrane. The use of 10% (w/v) water-soluble excipients (lactose or maltodextrin) as spray-drying adjuvants furnished redispersible powders (redispersibility index approximately 1.0) suitable for incorporation into hydrogels. All formulations showed a better controlled in vitro release of melatonin compared with the melatonin solution. The best controlled release results were achieved with hydrogels prepared with dried nanocapsules (hydrogels > redispersed dried nanocapsules > nanocapsule suspension > melatonin solution). The skin permeation studies demonstrated a significant modulation of the transdermal melatonin permeation for hydrogels prepared with redispersible nanocapsules. In this way, t...Continue Reading

References

Dec 12, 1997·Journal of Microencapsulation·J MolpeceresM Guzmán
Nov 18, 1998·Journal of Microencapsulation·B J LeeC K Kim
Nov 24, 1998·Biochemical Pharmacology·C E BeyerD Saphier
Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·K K KandimallaM Singh
Oct 13, 1999·Drug Development and Industrial Pharmacy·F LacouloncheM A Egea
Nov 9, 2000·Journal of Pineal Research·H J BrömmeD Peschke
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology· VijayalaxmiTerence S Herman
Apr 2, 2003·Cardiovascular Research·Russel J Reiter, Dun-Xian Tan
Dec 18, 2003·Drug Discovery Today·Sanjeeb K Sahoo, Vinod Labhasetwar
Mar 17, 2004·International Journal of Pharmaceutics·Shirui MaoDianzhou Bi
Jan 18, 2005·International Journal of Pharmaceutics·S R SchaffazickS S Guterres
May 18, 2005·International Journal of Pharmaceutics·E Garcia-GarciaP Couvreur
Mar 4, 2006·Biomaterials·Vaibhav DubeyNarendra Kumar Jain
Dec 8, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Patrice Tewa-TagneHatem Fessi
Apr 25, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vaibhav DubeyN K Jain
Jan 10, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Scheila R SchaffazickSílvia S Guterres
Jul 15, 2009·International Journal of Pharmaceutics·Anita HafnerJelena Filipović-Grcić
Jan 9, 2010·Journal of Biomedical Nanotechnology·Eliézer JägerAdriana R Pohlmann

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Citations

Oct 15, 2013·International Journal of Pharmaceutics·Henry T PengBob Cheung
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Roseane Fagundes RibeiroCristiane de Bona da Silva
Sep 22, 2015·Therapeutic Delivery·Sumeet K Singla, Vishal Sachdeva
Apr 24, 2018·Therapeutic Delivery·Aroonsri PripremCheardchai Soontornpas
Jul 3, 2019·Pharmaceutical Research·Edilson Ribeiro de Oliveira JuniorEliana Martins Lima
Nov 3, 2017·Pharmaceutical Development and Technology·Diego Fontana de AndradeRuy Carlos Ruver Beck
Oct 6, 2020·Frontiers in Endocrinology·Zeeshan Ahmad KhanAsamanja Chattoraj
Jan 27, 2021·International Journal of Pharmaceutics·Ricardo LorenzoniSilvia Stanisçuaski Guterres
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Talita Pizza Anunciato CasariniSilvia Stanisçuaski Guterres
May 1, 2021·Diseases·Alejandro RomeroAntonio Juberias
May 28, 2021·Drug Development and Industrial Pharmacy·Prashant K DeshmukhSanjay J Surana
Sep 16, 2018·International Journal of Pharmaceutics·Edilene Gadelha de OliveiraRuy Carlos Ruver Beck

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Methods Mentioned

BETA
light scattering
scanning electron microscopy

Software Mentioned

StatGraphics Plus
NTA
Almapal
MicroMath Scientist®

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