Hydrogels of collagen-inspired telechelic triblock copolymers for the sustained release of proteins

Journal of Controlled Release : Official Journal of the Controlled Release Society
H TelesF A de Wolf

Abstract

We studied the release of entrapped protein from transient gels made of thermosensitive, collagen-inspired ABA triblock copolymers with tailorable properties and with mid blocks of two different lengths (~37 kDa and ~73 kDa). These polymers were produced as heterologous proteins in recombinant yeast. By varying polymer length and concentration, the elastic properties of the hydrogels as well as their mesh size, swelling and erosion could be tuned. Whereas the volume of the investigated dense networks decreased in time as a result of temperature- and polymer concentration-dependent surface erosion, the release of entrapped protein was governed by a combination of gel erosion and protein diffusion. The prevalence of one or the other was strongly dependent on polymer concentration. Most importantly, the encapsulated protein was quantitatively released, which demonstrates that these hydrogels offer great potential as drug delivery systems.

References

Aug 24, 1999·Yeast·M W WertenF A de Wolf
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N A PeppasH Ichikawa
Nov 17, 2001·Biomacromolecules·R J StenekesW E Hennink
Jan 5, 2002·Advanced Drug Delivery Reviews·W E Hennink, C F van Nostrum
Jun 6, 2002·Drug Discovery Today·Piyush GuptaSanjay Garg
Nov 19, 2003·Advanced Drug Delivery Reviews·David OlsenJames Polarek
Mar 30, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Chunlin YangJames W Polarek
Oct 22, 2005·Applied Microbiology and Biotechnology·Julio BáezJames W Polarek
Nov 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Simon YoungAntonios G Mikos
Oct 10, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sivakumar Ramachandran, Yihua Bruce Yu
Mar 18, 2008·International Journal of Pharmaceutics·Sophie R Van TommeWim E Hennink
Apr 21, 2009·Biomacromolecules·Marc W T WertenFrits A de Wolf

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Citations

May 4, 2011·Biomacromolecules·Paulina J SkrzeszewskaJasper van der Gucht
Mar 13, 2012·Biomacromolecules·Catarina I F SilvaFrits A de Wolf
Mar 1, 2012·Chemical Reviews·Tina VermondenWim E Hennink
Mar 29, 2014·Expert Opinion on Drug Delivery·Tarun Garg, Amit K Goyal
Jun 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Robert PriceHamidreza Ghandehari
Jan 30, 2016·Chemical Reviews·Nicole G RicapitoDavid Putnam
Nov 10, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Satiesh Kumar RamadassBalaraman Madhan
Mar 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Roberta CensiWim E Hennink
Feb 20, 2013·Macromolecular Bioscience·Marie-Cécile KlakVéronique Larreta-Garde
Sep 4, 2013·Advanced Materials·Ekaterina V Skorb, Helmuth Möhwald
May 16, 2014·The Journal of Pharmacy and Pharmacology·Amit AlexanderShailendra Saraf
Feb 11, 2012·Neuroscience Letters·Kyle J Lampe, Sarah C Heilshorn
Jan 21, 2012·Biomedical Materials·Jerome A Werkmeister, John A M Ramshaw
Oct 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuzheng WuJianhua Rong
Jun 10, 2011·Biotechnology and Bioengineering·Catarina I F SilvaMarc W T Werten
Sep 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lies A L FliervoetTina Vermonden
Sep 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yongxiang LuoMichael Gelinsky

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