Hydrogels with enhanced mass transfer for transdermal drug delivery

Journal of Pharmaceutical Sciences
I ZhangD A Edwards

Abstract

The sonophoretic transport rates of monomeric insulin and vasopressin across human skin in vitro in the presence of a 20 kHz ultrasound field are shown to differ substantially depending on whether molecules enter the skin from a saline solution or from a viscous ultrasonic coupling medium (specifically, a methyl cellulose hydrogel or viscous sol). Theoretically, the reduction in sonophoretic transport caused by the hydrogels can be explained by boundary layers that form within the hydrogel owing to the relatively rapid rate of molecular transport across the (ultrasonically) permeated stratum corneum as well as poor diffusive mass transfer between the skin and gel. The results of in vitro experiments performed with an ac current accompanying the ultrasound show that the mass-transfer barrier posed by the hydrogel can be eliminated for both vasopressin and insulin by suppressing the diffusive boundary layers, indicating that relatively high rates of sonophoretic molecular transport across human skin are achievable when hydrogels are used as the ultrasound coupling medium as long as method is used to induce molecular mixing within the gel.

References

Jun 1, 1995·Journal of Pharmaceutical Sciences·S MitragotriR Langer
Aug 11, 1995·Science·S MitragotriR Langer
Sep 1, 1994·Journal of Pharmaceutical Sciences·D A Edwards, R Langer
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M R PrausnitzJ C Weaver
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·D A EdwardsR Langer

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Citations

Aug 31, 2001·Journal of Biomedical Materials Research·C S KwokB D Ratner
Apr 20, 2007·Pharmaceutical Research·E J ParkNadine Barrie Smith
Apr 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Omathanu Pillai, Ramesh Panchagnula
Mar 28, 2003·Ultrasound in Medicine & Biology·Nadine Barrie SmithK Kirk Shung
Aug 30, 2003·Ultrasound in Medicine & Biology·Nadine Barrie SmithK Kirk Shung
Aug 15, 2002·International Journal of Pharmaceutics·L Machet, A Boucaud
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N A PeppasH Ichikawa
May 14, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vinod Nair, Ramesh Panchagnula
Feb 3, 2005·Diabetes Technology & Therapeutics·Seungjun LeeNadine Barrie Smith
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anubhav AroraSamir Mitragotri
Sep 27, 2008·Expert Opinion on Drug Delivery·Nadine Barrie Smith
Nov 22, 2005·Expert Opinion on Drug Delivery·William G PittBryant J Staples
Dec 2, 2010·Expert Opinion on Drug Delivery·Baris E PolatRobert Langer
Jan 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Baris E PolatDaniel Blankschtein
Sep 22, 2007·Advanced Drug Delivery Reviews·Michael H Smolensky, Nicholas A Peppas
Oct 31, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Emiliano MaioneNadine Barrie Smith
Jul 10, 2019·Heliyon·Rajeshkumar Natwarlal VadgamaArvind Mallinath Lali
Dec 29, 2020·Chemical Reviews·Stephanie FuchsMinglin Ma

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