Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model

International Journal of Chronic Obstructive Pulmonary Disease
Xiaoyu LiuBaojian Xue

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive pulmonary disease caused by harmful gases or particles. Recent studies have shown that 2% hydrogen or hydrogen water is effective in the treatment and prevention of a variety of diseases. This study investigated the beneficial effects and the possible mechanisms of different hydrogen concentrations on COPD. A rat COPD model was established through smoke exposure methods, and inhalation of different concentrations of hydrogen was used as the intervention. The daily condition of rats and the weight changes were observed; lung function and right ventricular hypertrophy index were assessed. Also, white blood cells were assessed in bronchoalveolar lavage fluid. Pathologic changes in the lung tissue were analyzed using light microscopy and electron microscopy; cardiovascular structure and pulmonary arterial pressure changes in rats were observed using ultrasonography. Tumor necrosis factor alpha, interleukin (IL)-6, IL-17, IL-23, matrix metalloproteinase-12, tissue inhibitor of metalloproteinase-1, caspase-3, caspase-8 protein, and mRNA levels in the lung tissue were determined using immunohistochemistry, Western blot, and real-time polymerase chain reaction. The results s...Continue Reading

Citations

May 15, 2020·QJM : Monthly Journal of the Association of Physicians·S-T WangK-F Xu
Aug 16, 2017·Biochemical and Biophysical Research Communications·Yohei SuzukiKazuhisa Takahashi
Nov 26, 2020·Current Pharmaceutical Design·Shucun Qin
Dec 15, 2020·Current Pharmaceutical Design·Lei ZhangNan Huang

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BETA
protein assay
PCR

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SPSS
Vevo

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