Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase

Biochemical and Biophysical Research Communications
A P KulkarniI Richards

Abstract

Hydrogen peroxide, an ubiquitous biologically occurring peroxide, was found to stimulate the dioxygenase activity of soybean lipoxygenase at the physiologically attainable concentration. The increase in enzyme specific activity was directly proportional to hydrogen peroxide concentration up to 0.5 nM. A decrease in the stimulation of dioxygenase activity was observed at higher concentrations. At low enzyme concentration up to 28-fold stimulation was noted when the formation of lipid hydroperoxide was monitored spectrophotometrically. The stimulation was further confirmed by increased oxygen uptake. It is proposed that the mechanism for in vivo activation involves hydrogen peroxide.

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Citations

Aug 1, 1994·Journal of Biochemical Toxicology·S K Roy, A P Kulkarni
Jul 12, 2002·Phytotherapy Research : PTR·T SenA K Nag Chaudhuri
Dec 11, 2008·Protoplasma·Ladislav TamásIgor Mistrík
Jul 30, 1991·Biochimica Et Biophysica Acta·H W Gardner
Mar 2, 1995·Biochimica Et Biophysica Acta·A VianelloF Macrì
Sep 15, 1994·Biochimica Et Biophysica Acta·P RoyA P Kulkarni
Nov 17, 1994·Biochimica Et Biophysica Acta·F MacrìA Vianello
Nov 1, 1992·The International Journal of Biochemistry·J Z ByczkowskiA P Kulkarni
Oct 9, 1998·Progress in Lipid Research·E Blée
Apr 30, 2003·Antioxidants & Redox Signaling·Valerie B O'Donnell
Jul 17, 2001·Biochemical and Biophysical Research Communications·P SchroederH Sies
Aug 16, 2008·Journal of Ethnopharmacology·K T Mani Senthil KumarTuhinadri Sen
Mar 1, 2008·Plant Science : an International Journal of Experimental Plant Biology·Gloria Rodriguez BañuelosRobert Luis Vellanoweth
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Feb 1, 1991·Research Communications in Chemical Pathology and Pharmacology·A K Naidu, A P Kulkarni
Apr 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K A Akhilender NaiduA P Kulkarni
Jan 27, 2021·BMC Plant Biology·María E Sánchez-SandovalS M Teresa Hernández-Sotomayor
Jul 31, 1998·Archives of Biochemistry and Biophysics·M MaccarroneA Finazzi-Agrò
Oct 1, 1991·Cancer Letters·S K Roy, A P Kulkarni
Dec 22, 1999·Journal of Agricultural and Food Chemistry·M C PintoP Macías

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