Hydrogen peroxide induces cell proliferation and apoptosis in pulp of rats after dental bleaching in vivo: Effects of the dental bleaching in pulp

Archives of Oral Biology
F BenettiL T A Cintra

Abstract

This study provides an in vivo evaluation of the inflammatory response, levels of cell proliferation and apoptosis, and the presence of necrosis after dental bleaching with two concentrations of hydrogen peroxide (H2O2). Wistar rats were divided into Control (placebo gel), BLUE (20% H2O2, 1×50min), and MAXX (35% H2O2, 3×15min) groups. At 2 and 30days, the rats were killed (n=10). The jaws were processed for histology analysis and PCNA and Caspase-3-cleaved immunohistochemistry, and data were submitted to the Mann-Whitney or ANOVA test (P<0.05). At 2days, the MAXX group showed necrosis and the BLUE group revealed moderate inflammation on the occlusal third of the crown (P<0.05). At 30days, tertiary dentin had formed and there was an absence of inflammation. The level of cell proliferation was higher in the middle third of the BLUE group (P<0.05), and cervical of MAXX at 2days (P<0.05), decreasing at 30days. The apoptosis was present at 2days, particularly in the cervical third of the crown in the bleached groups (P<0.05), with a decrease only at 30days in the BLUE group (P<0.05). The concentration of H2O2 influences effects on the pulp tissue, where a higher concentration of H2O2 can cause necrosis in the pulp and a prolonged ef...Continue Reading

Citations

Dec 13, 2017·Clinical Oral Investigations·Francine BenettiLuciano Tavares Angelo Cintra
Jan 9, 2019·PloS One·Marjorie de Oliveira GallinariAndré Luiz Fraga Briso
Aug 15, 2019·Journal of Applied Oral Science : Revista FOB·Diana Gabriela SoaresCarlos Alberto de Souza Costa
Jan 30, 2019·Journal of Investigative and Clinical Dentistry·Lidiane M LouzadaLuciano T A Cintra
May 16, 2019·Oxidative Medicine and Cellular Longevity·Shengbin HuangYihuai Pan
Jul 16, 2019·Clinical Oral Investigations·Jéssica Galbiati BarbosaLuciano Tavares Angelo Cintra
Mar 22, 2020·Clinical Oral Investigations·Amanda Miyuki TerayamaLuciano Tavares Angelo Cintra
Dec 6, 2018·Brazilian Dental Journal·Francine BenettiLuciano Tavares Angelo Cintra
Jun 3, 2020·Restorative Dentistry & Endodontics·Livia Maria Alves Valentim da SilvaAndré Luiz Fraga Briso
Jun 11, 2020·Journal of Applied Oral Science : Revista FOB·Marina CarminattiLuciano Tavares Angelo Cintra
Feb 17, 2021·Biology of Reproduction·Haolin ZhangKentaro Nagaoka
Sep 2, 2021·Scientific Reports·Chang ChenRong Li

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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