Hydrogen peroxide inhibits exercise-induced increase of circulating stem cells with endothelial progenitor capacity

Free Radical Research
Tatsiana SuvoravaGeorg Kojda

Abstract

The number of circulating stem cells with endothelial progenitor capacity (EPCs) inversely correlates with the number of cardiovascular risk factors. In this study we sought to investigate the effects of vascular H(2)O(2) on circulating EPC levels. In C57BL/6 mice 3 weeks of freely moving or forced physical activity or voluntary exercise failed to increase circulating EPCs defined as double positive for Flk-1 and CD34, CD133 or Sca-1. Likewise, neither insertion of additional genes encoding for catalase (cat(++)) or eNOS nor eNOS knock-out changed EPCs in resting mice. In striking contrast, inhibition of catalase by aminotriazole strongly reduced circulating EPCs in sedentary cat(++) and their transgen-negative littermates (cat(n)), while forced or voluntary exercise training of cat(++) mice significantly increased the number of circulating EPCs. The latter effect was completely inhibitable by aminotriazole. These data suggest that endogenous vascular H(2)O(2) likely contributes to the impairment of important stem cell-induced vascular repair mechanisms in cardiovascular disease.

References

Feb 28, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Volker AdamsRainer Hambrecht
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Iman MomkenVladimir Veksler
Aug 24, 2004·Circulation Research·Carmen Urbich, Stefanie Dimmeler
Sep 15, 2004·Journal of the American College of Cardiology·Tatsiana SuvoravaGeorg Kojda
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Oct 12, 2005·Circulation·Tatsiana SuvoravaGeorg Kojda
Dec 13, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J P De BonoK M Channon
Mar 4, 2006·Experimental Biology and Medicine·Noelia Ardanaz, Patrick J Pagano
Oct 7, 2006·Stem Cells·David A IngramLaura S Haneline
Feb 6, 2008·Atherosclerosis·Gian Paolo FadiniAngelo Avogaro
Mar 20, 2008·Cardiovascular Research·Anna ZampetakiQingbo Xu
Jul 16, 2008·Journal of Molecular and Cellular Cardiology·Carmen UrbichStefanie Dimmeler

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Citations

Aug 31, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Francesca FeliceRossella Di Stefano
Nov 26, 2010·Antioxidants & Redox Signaling·Sven Moebius-WinklerVolker Adams
Jul 31, 2012·Current Cardiovascular Risk Reports·Nathan T JenkinsJaume Padilla
Dec 7, 2010·Journal of Cellular and Molecular Medicine·Vu Thao-Vi DaoGeorg Kojda
Feb 15, 2015·Biochemical and Biophysical Research Communications·Tatsiana SuvoravaGeorg Kojda
May 29, 2016·Biochemical Pharmacology·Vu Thao-Vi DaoGeorg Kojda

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