Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity

Nature Communications
Saskia F Erttmann, Nelson O Gekara

Abstract

Hydrogen peroxide (H2O2) has a major function in host-microbial interactions. Although most studies have focused on the endogenous H2O2 produced by immune cells to kill microbes, bacteria can also produce H2O2. How microbial H2O2 influences the dynamics of host-microbial interactions is unclear. Here we show that H2O2 released by Streptococcus pneumoniae inhibits inflammasomes, key components of the innate immune system, contributing to the pathogen colonization of the host. We also show that the oral commensal H2O2-producing bacteria Streptococcus oralis can block inflammasome activation. This study uncovers an unexpected role of H2O2 in immune suppression and demonstrates how, through this mechanism, bacteria might restrain the immune system to co-exist with the host.

References

Feb 1, 1996·Molecular Microbiology·B SpellerbergH R Masure
Jul 19, 2000·Infection and Immunity·K OverwegP W Hermans
Dec 9, 2000·International Journal of Medical Microbiology : IJMM·J E Alouf
Jul 11, 2001·FEBS Letters·V Borutaite, G C Brown
Oct 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·M Palmer
Jun 11, 2004·Nature·Sanjeev MariathasanVishva M Dixit
May 9, 2006·Antioxidants & Redox Signaling·James R Stone, Suping Yang
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Isabella Dalle-DonneAldo Milzani
Apr 17, 2007·Molecular Cell·Elizabeth A VealBrian A Morgan
Dec 12, 2007·The Journal of Experimental Medicine·Fayyaz S SutterwalaRichard A Flavell
Jan 5, 2008·Annual Review of Biochemistry·James A Imlay
Apr 15, 2008·Cell Host & Microbe·Sharon S MasterVojo Deretic
May 1, 2008·The Journal of Biological Chemistry·Paul A GrimsrudDavid A Bernlohr
May 24, 2008·Antioxidants & Redox Signaling·Marcel ZamockyChristian Obinger
Jul 8, 2008·Nature Immunology·Felix MeissnerArturo Zychlinsky
Nov 3, 2009·Lancet·Tom van der Poll, Steven M Opal
Dec 22, 2009·Nature Immunology·Rongbin ZhouJürg Tschopp
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Frank L van de VeerdonkMihai G Netea
Feb 20, 2010·Nature Reviews. Immunology·Jurg Tschopp, Kate Schroder
Mar 5, 2010·European Journal of Immunology·Fabio Martinon
Mar 31, 2010·Nature Immunology·Teresa Fernandes-AlnemriEmad S Alnemri
Jul 20, 2010·Cell Host & Microbe·Debra J TaxmanJenny P-Y Ting
Jun 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin WitzenrathBastian Opitz
Jun 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franz BauernfeindVeit Hornung
Oct 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rendong FangMasao Mitsuyama
Aug 4, 2012·Journal of Leukocyte Biology·Anna Rubartelli
Sep 6, 2012·The Journal of Biological Chemistry·Christine JulianaEmad S Alnemri
Oct 27, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eduardo Hernandez-CuellarMasao Mitsuyama
Dec 12, 2012·Annual Review of Immunology·Jakob von MoltkeRussell E Vance
Dec 19, 2012·Cell Host & Microbe·Christopher N LaRock, Brad T Cookson
Jan 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Araceli Perez-LopezVianney Ortiz-Navarrete

❮ Previous
Next ❯

Citations

Jul 1, 2020·Antioxidants & Redox Signaling·Raffaella Bonavita, Mikko O Laukkanen
Jul 24, 2020·Chemical Communications : Chem Comm·Jordan MangueStéphane Torelli
Apr 15, 2020·Antioxidants & Redox Signaling·Mobarak Abu MraheilRudolf Lucas
Jul 22, 2020·Analytical and Bioanalytical Chemistry·Giada Caniglia, Christine Kranz
Jan 12, 2021·Frontiers in Immunology·Chun-Hsien WuKuo-Feng Hua
Jan 12, 2021·Frontiers in Immunology·Surabhi SurabhiNikolai Siemens
Nov 4, 2020·International Journal of Molecular Sciences·Amel SamiC Anthony Ryan
Apr 10, 2021·Frontiers in Cellular and Infection Microbiology·Yamil Sanchez-Rosario, Michael D L Johnson
May 18, 2021·Frontiers in Molecular Biosciences·Alistair Tweedie, Tracy Nissan
Aug 10, 2021·Rare Metals·Meng DingShi-Fang Luan
Nov 9, 2021·Frontiers in Immunology·Abhinit NagarJonathan A Harton

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Assay
ELISAs
X ray
X-ray

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.