PMID: 22576533May 12, 2012Paper

Hydrogen potential of antibiotic solutions subjected to environmental conditions: a preliminary trial

Revista da Escola de Enfermagem da U S P
Cintia MonteiroMavilde Da Luz Gonçalves Pedreira

Abstract

This experimental study was performed to assess the hydrogen potential (pH) of the antimicrobials ceftriaxone sodium, vancomycin hydrochloride, metronidazole, penicillin G potassium, and amikacin sulphate, following reconstitution, diluted with NaCl 0.9% (SF) and glucose solution 5% (GS), at eight different time intervals and under the normal daily conditions of lighting and temperature within the hospital unit (no air conditioning). The objective of this study was to verify the changes in the acid-base behavior of the solutions, which indicate chemical instability and can be associated with complications during intravenous therapy. Of the 186 analyzed pH values, there were no variations greater than 1.0 and no physical alterations visible to the naked eye. All solutions had a pH less than 7, and there were no significant differences for clinical practice regarding the diluent. The mean pH values after dilution with SF and GS for vancomycin hydrochloride, metronidazole, and amikacin sulphate are a risk factor for the development of intravenous complications due to their extreme acidity.

References

Jul 7, 1984·The Medical Journal of Australia·J Turnidge
Oct 1, 1996·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·R J PlumridgeS R Langton
Sep 20, 1997·The New England Journal of Medicine·D N GilbertJ E Leggett
Aug 28, 2002·Scandinavian Journal of Infectious Diseases·Peter LanbeckOtto Paulsen
Aug 11, 2004·Revista latino-americana de enfermagem·Paulo Celso Prado Telles Filho, Silvia Helena de Bortoli Cassiani
Feb 6, 2009·Revista da Escola de Enfermagem da U S P·Maria Clara Padovani de SouzaAdriano Max Moreira Reis
Jun 16, 2010·Revista latino-americana de enfermagem·Renata Maria Coelho CrepaldiMavilde da Luz Gonçalves Pedreira

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Citations

Jan 24, 2020·British Journal of Nursing : BJN·Chong Xue YingSoon Lean Keng

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