Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats

Experimental and Molecular Pathology
Yu ZhaiXinli Huang

Abstract

Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, to our knowledge, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. Our experiments exhibited that gas exchange dysfunction and lung tissue inflammation were observed in animals exposed to CLP. Hydrogen-rich saline treatment significantly attenuated lung injury as indicated by significantly improved gas exchange and histological changes in the lung and significantly reduced lung water content (LWC) and neutrophil infiltration 8h after CLP. Lipid peroxidation and DNA oxidation in the lung tissue were significantly reduced along with a decreased nitrotyrosine content and maintained superoxide dismutase activity in the presence of hydrogen, demonstrating antioxidant role of hydrogen in CLP-induced ALI. Importantly, hydrogen-rich saline treatment significantly inhibited the activation of p-p38 and NF-κB while suppressing the production of several proinflammatory mediators. This observation indicated that hydrogen-rich saline peritoneal injection improves histological ...Continue Reading

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Citations

Jan 30, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Melike DemirCengizhan Sezgi
Mar 31, 2016·Scientific Reports·Yi ZhangChun-Lei Jiang
Jun 27, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jia WangJiong Zhang
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Feb 20, 2021·Journal of Biochemical and Molecular Toxicology·Mustafa CicekMehmet Demir
Apr 27, 2021·Experimental Biology and Medicine·Lini QuanHuacheng Zhou

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