Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats

Brain Research
Runfa TianBaiyun Liu

Abstract

Inflammation and oxidative stress are the two major causes of apoptosis after traumatic brain injury (TBI). Most previous studies of the neuroprotective effects of hydrogen-rich water on TBI primarily focused on antioxidant effects. The present study investigated whether hydrogen-rich water (HRW) could attenuate brain damage and inflammation after traumatic brain injury in rats. A TBI model was induced using a controlled cortical impact injury. HRW or distilled water was injected intraperitoneally daily following surgery. We measured survival rate, brain edema, blood-brain barrier (BBB) breakdown and neurological dysfunction in all animals. Changes in inflammatory cytokines, inflammatory cells and Cho/Cr metabolites in brain tissues were also detected. Our results demonstrated that TBI-challenged rats exhibited significant brain injuries that were characterized by decreased survival rate and increased BBB permeability, brain edema, and neurological dysfunction, while HRW treatment ameliorated the consequences of TBI. HRW treatment also decreased the levels of pro-inflammatory cytokines (TNF-α, IL-1β and HMGB1), inflammatory cell number (Iba1) and inflammatory metabolites (Cho) and increased the levels of an anti-inflammatory cy...Continue Reading

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Citations

Feb 23, 2017·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Aug 5, 2017·Acta Pharmacologica Sinica·Ying-Liang LiuHeng-Li Tian
Jun 26, 2018·Frontiers in Neuroscience·Xiaoru CheSheng Chen
Jan 17, 2020·Pakistan Journal of Biological Sciences : PJBS·Liangtong LiFulin Liu
Nov 6, 2018·Molecular Medicine Reports·Xiuzhen HaoHuixiao Dong
Oct 21, 2020·Neuroscience Bulletin·Wei ChenShu-Cun Qin
May 5, 2021·Journal of Neurotrauma·Samuel S ShinTodd J Kilbaugh
Aug 9, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiongge HuAnwen Shao
Nov 14, 2020·Current Pharmaceutical Design·Yasushi Satoh

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