Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model

Oxidative Medicine and Cellular Longevity
Naofumi TamakiHiro-O Ito

Abstract

The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. A circular excisional wound was created in the oral palatal region, and the wound healing process was observed. The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed. In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue. In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation...Continue Reading

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Citations

Jun 9, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaki YamamotoKazumasa Orihashi
Jul 4, 2019·Advanced Healthcare Materials·Gaoxin ZhouQianjun He
Nov 19, 2019·Acta Biochimica Et Biophysica Sinica·Geru TaoShucun Qin
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Apr 3, 2020·The Journal of Investigative Dermatology·Wei FangJinhua Xu
Aug 28, 2021·International Journal of Molecular Sciences·Islamy Rahma HutamiEiji Tanaka

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Methods Mentioned

BETA
biopsy
PCR
electrophoresis
ELISA

Software Mentioned

SPSS
Bio
Image J
Plex Manager

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