Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote

Scientific Reports
Jingjing JiangGerry R Boss

Abstract

Hydrogen sulfide is a highly toxic gas-second only to carbon monoxide as a cause of inhalational deaths. Its mechanism of toxicity is only partially known, and no specific therapy exists for sulfide poisoning. We show in several cell types, including human inducible pluripotent stem cell (hiPSC)-derived neurons, that sulfide inhibited complex IV of the mitochondrial respiratory chain and induced apoptosis. Sulfide increased hydroxyl radical production in isolated mouse heart mitochondria and F2-isoprostanes in brains and hearts of mice. The vitamin B12 analog cobinamide reversed the cellular toxicity of sulfide, and rescued Drosophila melanogaster and mice from lethal exposures of hydrogen sulfide gas. Cobinamide worked through two distinct mechanisms: direct reversal of complex IV inhibition and neutralization of sulfide-generated reactive oxygen species. We conclude that sulfide produces a high degree of oxidative stress in cells and tissues, and that cobinamide has promise as a first specific treatment for sulfide poisoning.

References

Feb 1, 1979·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·R P Smith, R E Gosselin
May 1, 1976·Archives of Environmental Health·R P SmithH Kruszyna
Jan 1, 1992·Annual Review of Pharmacology and Toxicology·R J ReiffensteinS H Roth
Jan 1, 1991·American Journal of Industrial Medicine·B TvedtT Mathiesen
May 7, 1969·Journal of the American Chemical Society·J H BaystonM E Winfield
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·J L Way
Sep 1, 1996·Journal of Neurochemistry·E M MillsG E Isom
Oct 1, 1996·Occupational Medicine·T L Guidotti
May 1, 1997·American Journal of Industrial Medicine·P A HesselM Nakaza
Mar 17, 2000·Free Radical Biology & Medicine·L J Roberts, J D Morrow
Sep 27, 2002·Current Opinion in Pharmacology·Sanjay Tickoo, Steven Russell
Aug 28, 2003·Southern Medical Journal·Kaye H Kilburn
Jan 6, 2005·The Journal of Biological Chemistry·Kate E BroderickGerry R Boss
Feb 1, 2005·Biochimica Et Biophysica Acta·Michael J Davies
Apr 26, 2006·Experimental Biology and Medicine·Kate E BroderickGerry R Boss
Dec 6, 2006·Drug Metabolism Reviews·Don H TruongPeter J O'Brien
Feb 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marc GoubernFrédéric Bouillaud
May 4, 2007·Molecular Cancer Research : MCR·Matias S Attene-RamosMichael J Plewa
Oct 20, 2009·Nature Methods·Tongxiang LinSheng Ding
Nov 12, 2009·Science Signaling·Asif K MustafaSolomon H Snyder
Apr 28, 2010·Analytical Chemistry·William C BlackledgeGerry R Boss
May 28, 2010·Toxicology and Industrial Health·Kaye H KilburnMichael R Gray
Aug 14, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Adriano ChanTimothy D Bigby
Apr 5, 2011·Nature Methods·Keisuke OkitaShinya Yamanaka
Jul 12, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Adriano ChanGerry R Boss
Jan 31, 2012·Cellular Signalling·Paul D RayYoshiaki Tsuji
Oct 30, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katalin MódisCsaba Szabo
Jan 15, 2014·Biochimica Et Biophysica Acta·Omer KabilRuma Banerjee
Apr 11, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·M BrennerG R Boss
Jan 13, 2015·European Journal of Inorganic Chemistry·Denis S SalnikovGerry R Boss

❮ Previous
Next ❯

Citations

Jul 22, 2016·Annals of the New York Academy of Sciences·Wilson RumbeihaArthi Kanthasamy
Jan 28, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Kun LvPinggui Yi
Apr 13, 2017·Journal of Biotechnology·Richard J JohnsonTorben Lund Skovhus
Feb 10, 2017·Free Radical Biology & Medicine·Leonid LivshitsEinav Gross
Jan 11, 2018·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Poojya AnantharamWilson K Rumbeiha
Dec 15, 2017·Annals of the New York Academy of Sciences·Poojya AnantharamWilson K Rumbeiha
Jan 26, 2018·Scientific Reports·José Maria Clemente da Silva FilhoFrancisco Chagas Marques
Feb 7, 2019·The Journal of Toxicological Sciences·Kana UnumaKoichi Uemura
May 8, 2019·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Patrick C NgVikhyat S Bebarta
Jun 20, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kiran DyamenahalliElizabeth J Kovacs
Oct 19, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Humberto Morales-LoredoNancy L Kanagy
Nov 16, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Patrick C NgVikhyat S Bebarta
May 19, 2019·Scientific Reports·Moein Jahanbani Veshareh, Hamidreza M Nick
Jun 14, 2019·Angewandte Chemie·Chun-Tao YangMing Xian
Feb 2, 2020·Intensive Care Medicine Experimental·Eizo Marutani, Fumito Ichinose
Sep 22, 2020·Annals of the New York Academy of Sciences·Praveen K BalneRajiv R Mohan
Sep 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana HipólitoJacinta Serpa
Jul 9, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hema KalyanaramanRenate B Pilz
Jul 19, 2017·Annals of the New York Academy of Sciences·Poojya AnantharamWilson K Rumbeiha
Apr 3, 2020·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Joseph K MaddryVikhyat S Bebarta
Aug 8, 2019·Nature Communications·Gerburg K SchwaerzerRenate B Pilz
Apr 28, 2019·Nutrients·Levi M TeigenAlexander Khoruts
Apr 2, 2020·Annals of the New York Academy of Sciences·Tara B Hendry-HoferVikhyat S Bebarta
Jul 6, 2017·Applied Biochemistry and Biotechnology·Hamid BeyzaeiMohammadreza Moghaddam-Manesh
Apr 11, 2018·Antioxidants & Redox Signaling·Christopher HineJames R Mitchell
Oct 23, 2019·Neural Regeneration Research·Rubaiya TabassumJunyang Jung
Apr 29, 2020·Chemical Communications : Chem Comm·Parvathy MiniKellie L Tuck
Feb 1, 2021·Ageing Research Reviews·Alexander S SokolovAlexey A Moskalev
Jan 8, 2021·Cell and Tissue Research·Denusha ShresthaChandrashekhar Charavaryamath
Nov 24, 2020·British Journal of Cancer·Vasco D B BonifácioJoão B Vicente
Aug 25, 2019·Medical Hypotheses·Pierre P Kamoun

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
electron paramagnetic resonance

Software Mentioned

Prism
WinSim

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Denise FernándezLewis S Nelson
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Matt Brenner
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
M BrennerGerry R Boss
Chūdoku kenkyū : Chūdoku Kenkyūkai jun kikanshi = The Japanese journal of toxicology
Hideki Nasu, Masahiro Shinozaki
© 2022 Meta ULC. All rights reserved