Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress

Oxidative Medicine and Cellular Longevity
Ya-Dan BaiYi-Chun Zhu

Abstract

This study aims to investigate the influence of excessive oxidative stress on cardiac injury during acute myocardial ischemia (AMI), with a focus on apoptosis, autophagy, and inflammatory cell infiltration, and to detect the role of hydrogen sulfide (H2S) in this process. We found that SOD1 knockout (KO) mice showed excessive oxidative stress and exacerbated myocardium injury after AMI. Increased apoptosis and inflammation response in the ischemic myocardium contribute to this deterioration, whereas enhanced autophagy plays a protective role. Myocardial inflammation after AMI was much more severe in SOD1 KO mice than in wild-type mice. Pretreatment with the H2S donor NaHS reduced autophagy and apoptosis levels in the ischemic myocardium and alleviated the regional inflammation response in the cardiac tissues of SOD1 KO mice. Moreover, autophagy and apoptosis levels were significantly enhanced in SOD1 knockdown primary neonatal rat cardiomyocytes (NRCMs) under glucose deprivation. Pretreatment with NaHS can partially inhibit this elevation. Taken together, we found that excessive oxidative stress can aggravate cardiac injury during AMI. Exogenous H2S can alleviate cardiac injury during AMI by reducing apoptosis and inflammation ...Continue Reading

References

Aug 28, 1997·Biochemical and Biophysical Research Communications·R HosokiH Kimura
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P WangJ L Zweier
Jan 30, 1999·Journal of Molecular and Cellular Cardiology·Z ChenB H Chua
Dec 2, 2000·Science·D J Klionsky, S D Emr
Nov 5, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Leo G KevinDavid F Stowe
Nov 26, 2003·The Journal of Clinical Investigation·Xueping QuBeth Levine
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lin YanStephen F Vatner
Oct 6, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jin-Song BianPhilip Keith Moore
Sep 23, 2006·The Journal of Biological Chemistry·Daniel MeleyAlfred J Meijer
May 23, 2007·The New England Journal of Medicine·Steven E Nissen, Kathy Wolski
Jul 4, 2007·The Journal of Clinical Investigation·Hongxin ZhuJoseph A Hill
Jul 17, 2007·Cardiovascular Research·Wen-Jie CaiYi-Chun Zhu
Apr 9, 2008·Physiological Reviews·Elizabeth Murphy, Charles Steenbergen
Aug 19, 2008·Biochimica Et Biophysica Acta·Eeva-Liisa Eskelinen, Paul Saftig
Nov 11, 2008·Current Pharmaceutical Design·Giuseppe M C RosanoGiuseppe Barbaro
May 30, 2009·Free Radical Biology & Medicine·Lu Miao, Daret K St Clair
Oct 22, 2009·Antioxidants & Redox Signaling·Ming-Jie WangYi-Chun Zhu
Feb 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Ling-Ling YaoYi-Chun Zhu
Jun 10, 2010·Circulation·Matthias NahrendorfFilip K Swirski
Mar 15, 2011·Antioxidants & Redox Signaling·Daolin TangMichael T Lotze
May 13, 2011·Trends in Cell Biology·Jacob M Gump, Andrew Thorburn
Oct 13, 2011·The Journal of Pathology·Sunandini SridharAna Maria Cuervo
Jan 10, 2012·Circulation Research·Nikolaos G Frangogiannis
Dec 29, 2013·Trends in Endocrinology and Metabolism : TEM·Dieter A Kubli, Asa B Gustafsson
Mar 26, 2014·Nature Reviews. Cardiology·Nikolaos G Frangogiannis
May 9, 2014·The American Journal of Medicine·James E DalenRonald S Weinstein
Sep 27, 2014·International Journal of Environmental Research and Public Health·Fernando FreitasSolange C Garcia
Jan 31, 2015·Circulation Research·David I Brown, Kathy K Griendling
Feb 6, 2015·The Journal of Clinical Investigation·Sergio LavanderoJoseph A Hill
Feb 28, 2015·Circulation Research·Michael Hristov, Christian Weber
Jul 15, 2015·Handbook of Experimental Pharmacology·Madhav Bhatia

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Citations

May 10, 2019·Chemical Communications : Chem Comm·Hong YaoShengtao Xu
Oct 8, 2019·Antioxidants & Redox Signaling·Alma MartelliVincenzo Calderone
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Xing ChangJiahui Sun

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Methods Mentioned

BETA
flow cytometry
Assay
transfection
electron microscopy
ELISA

Software Mentioned

ImageJ

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