Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Experimental and Therapeutic Medicine
Da-Sen YuanXiao-Qing Tang

Abstract

Acute liver failure (ALF) is a devastating clinical syndrome with a high mortality rate if not treated promptly. Previous studies have demonstrated the beneficial effects of hydrogen sulfide (H2S) on the brain and liver. The present study aimed to investigate the potential protective effects of H2S in ALF. A mouse model of ALF was established following treatment with thioacetamide (TAA). Mice with TAA-induced ALF were intraperitoneally injected with 30 or 100 µmol/kg/day sodium hydrosulfide (NaHS; a H2S donor drug) for two weeks. According to results from novel object recognition and Y-maze tests, in the present study, NaHS treatment alleviated cognitive deficiency and preserved spatial orientation learning ability in TAA-induced ALF mice compared with those of untreated mice. In addition, NaHS treatment reduced serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and the concentration of ammonia compared with those that received control treatment, resulting in weight loss prevention. These findings suggested a beneficial effect of H2S on liver function. In conclusion, results from the present study suggested that H2S treatment may alleviate cognitive deficiency and hepatic dysfunction in mice with ALF, indi...Continue Reading

Related Concepts

Related Feeds

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Related Papers

Cranio : the Journal of Craniomandibular Practice
Tasha Turzo
Deutsches Ärzteblatt International
Ali CanbayMichael P Manns
Current Gene Therapy
Chuan-Long ZhuRen-Tao Gao
Journal of Clinical and Experimental Hepatology
Shalimar
© 2022 Meta ULC. All rights reserved