Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release

Journal of Vascular Surgery
Bo TangXueying Sun

Abstract

Infrarenal aortic cross-clamping (IAC) is a common procedure during infrarenal vascular operations. It often causes ischemia-reperfusion injury to lower limbs, resulting in systemic inflammation response and damage to remote organs (particularly lungs). Hydrogen sulfide (H2S) is a gaseous mediator that has been shown to have a protective effect against lung injury. Wistar rats underwent IAC for 2 hours, followed by 4 hours of reperfusion. GYY4137 (a slow-releasing H2S donor) and dl-propargylglycine (PAG, an inhibitor of cystathionine γ-lyase) were preadministered to rats 1 hour before IAC, and their effects on severity of lung injury and related mechanisms were investigated. IAC induced a significant increase in plasma levels of H2S, H2S-synthesizing activity, and cystathionine γ-lyase expression in lung tissues compared with sham operation. Administration of GYY4137 significantly increased the levels of H2S but had little effect on H2S-synthesizing activity, whereas PAG reduced H2S levels and H2S-synthesizing activity. Preadministration of GYY4137 significantly attenuated acute lung injury induced by IAC, evidenced by reduced histologic scores and wet lung contents; improved blood gas parameters; reduced cell counts and protei...Continue Reading

Citations

Nov 28, 2019·Journal of Cellular Physiology·Eman A ElbassuoniWagdу N Habeeb
Feb 2, 2018·Experimental and Therapeutic Medicine·Jin-Zhuo NingCheng-Cheng Xiao
Jun 10, 2020·American Journal of Physiology. Cell Physiology·Guangdong Yang
Oct 24, 2019·Antioxidants & Redox Signaling·Dawn Sijin NinLih-Wen Deng
Jun 25, 2016·Mediators of Inflammation·Mi LiuTianxin Yang
Mar 3, 2017·Oxidative Medicine and Cellular Longevity·Sashko Georgiev SpassovSimone Faller
Dec 19, 2020·Intensive Care Medicine Experimental·Tamara MerzOscar McCook
May 22, 2021·Archives of Biochemistry and Biophysics·Jiechun ZhuGuangdong Yang

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