Hydrogen Sulfide Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway in Type 2 Diabetic Rats

Frontiers in Physiology
Tao JiangXiangqi Lv

Abstract

Lung ischemia-reperfusion (IR) injury remains a significant factor for the early mortality of lung transplantations. Diabetes mellitus (DM) is an independent risk factor for 5-year mortality following lung transplantation. Our previous study showed that DM aggravated lung IR injury and that oxidative stress played a key role in this process. Previously, we demonstrated that hydrogen sulfide (H2S) protected against diabetic lung IR injury by suppressing oxidative damage. This study aimed to examine the mechanism by which H2S affects diabetic lung IR injury. High-fat-diet-fed streptozotocin-induced type 2 diabetic rats were exposed to GYY4137, a slow-releasing H2S donor with or without administration of EX527 (a SIRT1 inhibitor), and then subjected to a surgical model of IR injury of the lung. Lung function, oxidative stress, cell apoptosis, and inflammation were assessed. We found that impairment of lung SIRT1 signaling under type 2 diabetic conditions was further exacerbated by IR injury. GYY4137 treatment markedly activated SIRT1 signaling and ameliorated lung IR injury in type 2 DM animals by improving lung functional recovery, diminishing oxidative damage, reducing inflammation, and suppressing cell apoptosis. However, these...Continue Reading

References

Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Jun 3, 2004·The Journal of Endocrinology·S H TorresH J Finol
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Dec 22, 2005·PLoS Biology·Laura BordoneLeonard Guarente
Mar 15, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shu Fang Liu, Asrar B Malik
Aug 19, 2006·Respiratory Physiology & Neurobiology·A KaminskiC Stamm
Mar 10, 2007·The EMBO Journal·Zachary Gerhart-HinesPere Puigserver
Apr 21, 2007·Circulation Research·Ralph R AlcendorJunichi Sadoshima
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ilwola MattagajasinghKaikobad Irani
Jun 10, 2008·Chronic Respiratory Disease·L M E Kuitert
Sep 28, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieMarshall I Hertz
Nov 10, 2010·Circulation·Chiao-Po HsuJunichi Sadoshima
Jan 15, 2011·Nature Reviews. Immunology·Marc Y Donath, Steven E Shoelson
May 17, 2011·The Journal of Surgical Research·Michael S KasparekMichael G Sarr
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenPaul Z Zimmet
May 12, 2012·The International Journal of Biochemistry & Cell Biology·Sarah J ChappleGiovanni E Mann
Sep 14, 2012·The Review of Diabetic Studies : RDS·Dario PitoccoGiovanni Ghirlanda
Mar 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Bridgette F PeakeJohn W Calvert
Nov 8, 2013·Diabetes & Metabolism Journal·Munehiro Kitada, Daisuke Koya
Jan 10, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K L HackmanL A Bach
Jul 11, 2014·American Journal of Respiratory Cell and Molecular Biology·Pengyu ZhangXin Zhou
Jul 16, 2014·Journal of Diabetes Research·Liang-Jun Yan
Apr 8, 2015·Nature Reviews. Drug Discovery·John L Wallace, Rui Wang
Jun 27, 2015·European Heart Journal·Stephan WinnikChristian M Matter
Oct 23, 2015·Cardiovascular Diabetology·Mingge DingXiaoming Wang
Feb 29, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mamoru TakahashiHiroshi Date
Aug 9, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qing-Tao MengZhong-Yuan Xia
Nov 27, 2016·Redox Biology·Jinzi WuLiang-Jun Yan
Feb 17, 2017·Aging and Disease·Hong ZhengLiang-Jun Yan
Aug 16, 2017·The Journal of Surgical Research·Linlin SongXiaoguang Cui
Jan 20, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yu SunWeihua Zhang

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Citations

Dec 12, 2020·Frontiers in Endocrinology·Teng MengBaohua Liu
Jun 3, 2021·Biomolecules·Saadullah KhattakDong-Dong Wu
May 22, 2021·Archives of Biochemistry and Biophysics·Jiechun ZhuGuangdong Yang
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·George J DugbarteyAlp Sener

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Methods Mentioned

BETA
lavage
Assay
co-immunoprecipitation
Enzyme-Linked
enzyme-linked immunosorbent assay
MDA
acetylation

Software Mentioned

Prism
GraphPad

Related Concepts

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