Hydrogen sulfide and carbon monoxide are in synergy with each other in the pathogenesis of recurrent febrile seizures.

Cellular and Molecular Neurobiology
Ying HanJunbao Du

Abstract

1. The purpose of the present study was to investigate the interaction between hydrogen sulfide (H(2)S) and carbon monoxide (CO) during recurrent febrile seizures (FS) 2.H(2)S and CO are important intra- and intercellular messengers, regulating various brain functions. Our recent studies showed that both of them alleviate the hippocampal damage induced by recurrent FS. In the present study, on a rat model of recurrent FS, we found that hydroxylamine (an inhibitor of cystathionine b-synthase, CBS) reduced CO level and down regulated heme oxygenase (HO-1) expression, while NaHS (a donor of H(2)S) elevated CO level and upregulated HO-1 expression. ZnPP-IX (an inhibitor of HO-1) decreased H(2)S formation and down regulated CBS expression, while hemin (which increases the production of endogenous CO) enhanced H(2)S formation and elevated CBS expression. 3. Our data demonstrate that endogenous H(2)S and CO are in synergy with each other in recurrent FS.

References

Sep 1, 1966·Toxicology and Applied Pharmacology·R P Smith, R A Abbanat
Jan 1, 1984·Critical Reviews in Toxicology·R O BeauchampD A Andjelkovich
Dec 1, 1995·Brain : a Journal of Neurology·J Maher, R S McLachlan
Jun 6, 1998·Canadian Journal of Physiology and Pharmacology·R Wang
Jan 30, 1999·Epilepsia·W JiangN C de Lanerolle
Nov 4, 2000·The American Journal of Psychiatry·S H Snyder, C D Ferris
Mar 28, 2001·Annals of the New York Academy of Sciences·P NavarraA Grossman
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
Apr 2, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Elisa FiumanaCharles W Leffler
Dec 16, 2003·Biochemical and Biophysical Research Communications·Hui YanChaoshu Tang
Dec 19, 2003·Annals of Neurology·Ying-Chao ChangChao-Ching Huang
Feb 10, 2004·Biochemical and Biophysical Research Communications·Zhi-Xian Yang, Jiong Qin
Jan 5, 2005·Biochemical and Biophysical Research Communications·Ying HanJunbao Du

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Citations

Apr 11, 2012·Organic Letters·Chunrong LiuMing Xian
Oct 8, 2011·Circulation Research·Asif K MustafaSolomon H Snyder
Jul 20, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Robert C Hider, Xiao L Kong
Sep 20, 2006·Expert Opinion on Therapeutic Targets·Hong Pyo KimAugustine M K Choi
Apr 14, 2009·Biochimica Et Biophysica Acta·Kenneth R Olson
Feb 9, 2011·European Journal of Pharmacology·Rajamanickam Baskar, Jinsong Bian
Apr 21, 2016·Analytical Chemistry·Yen Leng PakJuyoung Yoon
May 10, 2016·Analytical Chemistry·Armen ShamirianPreston T Snee
Dec 17, 2014·Chemical Communications : Chem Comm·Longwei HeHaipeng Wei
Sep 8, 2011·Angewandte Chemie·Chunrong LiuMing Xian
Jan 24, 2019·Organic & Biomolecular Chemistry·Hui ZhangXiangzhi Song
Oct 20, 2007·Nature Reviews. Drug Discovery·Csaba Szabó
Jan 5, 2018·The Journal of Biological Chemistry·Weining NiuShasha Yan
Dec 22, 2014·Reviews in the Neurosciences·Wen-Lin ChenXiao-Qing Tang
Sep 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julie FurneMichael D Levitt
Nov 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryan A DombkowskiKenneth R Olson
Apr 4, 2013·Chemical Communications : Chem Comm·Wen SunXiaojun Peng
Jul 4, 2018·Clinical Science·Percíllia V S Oliveira, Francisco R M Laurindo
Jun 16, 2011·Journal of the American Chemical Society·Alexander R LippertChristopher J Chang
Nov 27, 2021·Analytical and Bioanalytical Chemistry·Yu LuoHui Gu

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