Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes

Basic Research in Cardiology
Ioanna AndreadouAndreas Papapetropoulos

Abstract

Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

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Nov 26, 2015·Expert Opinion on Drug Discovery·Vincenzo CalderoneMaria C Breschi
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Jul 19, 2021·Basic Research in Cardiology·Ioanna AndreadouRainer Schulz

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