Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling

Journal of Hypertension
Lin XiaoYuming Wu

Abstract

We aimed to elucidate the ameliorative effect of hydrogen sulfide (H2S) on endothelium-dependent relaxation disturbances via peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase (PPARδ/eNOS) pathway activation in hypertensive patients and rats. Renal arteries were collected from normotensive and hypertensive patients who underwent nephron-sparing surgery. Renal arteries from 37 patients were cultured with or without sodium H2S (NaHS) 50 μmol/l. The rats were randomly divided into four groups: Sham; Sham + NaHS, two kidneys; one clipped (2K1C); and 2K1C + NaHS. Mean arterial pressure was measured by tail-cuff plethysmography. A microvessel recording technique was used to observe the effect of NaHS on endothelium-dependent relaxation. Plasma H2S concentrations were detected using the monobromobimane method. Real-time PCR and western blotting were used to assess mRNA and protein levels of AT1, cystathionine γ-lyase, PPARδ, and phosphor-eNOS. Laser confocal scanning microscopy measured intracellular NO production in human umbilical vein endothelial cells. NaHS improved endothelial function in hypertensive humans and rats. The 20-week administration of NaHS to 2K1C rats lowered the mean arterial pressur...Continue Reading

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Citations

Feb 1, 2018·Journal of Hypertension·Mark C Chappell
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Qin Yang, Guo-Wei He
Feb 7, 2019·The Pharmacogenomics Journal·Santiago CuevasPedro A Jose
Mar 7, 2021·International Journal of Molecular Sciences·Yi-Zhen WangDong-Dong Wu
Apr 4, 2021·Antioxidants·Valerio CicconeLucia Morbidelli
Jun 11, 2021·Stroke; a Journal of Cerebral Circulation·T Michael De SilvaFrank M Faraci

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