Mar 30, 2016

Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress

Oxidative Medicine and Cellular Longevity
Rui YangYu-Ming Wu


In this study, the vitamin D3 plus nicotine (VDN) model of rats was used to prove that H2S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC). Besides, H2S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues. The effect of H2S on alleviating VC and phenotype transformation of VSMC can be blocked by TM, while PBA also alleviated VC and phenotype transformation of VSMC that was similar to the effect of H2S. These results suggest that H2S may alleviate rat aorta VC by inhibiting ERS, providing new target and perspective for prevention and treatment of VC.

  • References33
  • Citations3


  • References33
  • Citations3


Mentioned in this Paper

Benzeneboronic acid
Muscle, Smooth, Vascular
TAGLN gene
Bone Development
Signaling Molecule
Arachis oil
Calcium [EPC]
Lymphoma, Non-Hodgkin
HSPA5 wt Allele

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