Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins

International Journal of Molecular Sciences
Chien-Ning Hsu, You-Lin Tain

Abstract

Adverse environments occurring during kidney development may produce long-term programming effects, namely renal programming, to create increased vulnerability to the development of later-life hypertension and kidney disease. Conversely, reprogramming is a strategy aimed at reversing the programming processes in early life, even before the onset of clinical symptoms, which may counter the rising epidemic of hypertension and kidney disease. Hydrogen sulfide (H₂S), the third gasotransmitter, plays a key role in blood pressure regulation and renal physiology. This review will first present the role of H₂S in the renal system and provide evidence for the links between H₂S signaling and the underlying mechanisms of renal programming, including the renin⁻angiotensin system, oxidative stress, nutrient-sensing signals, sodium transporters, and epigenetic regulation. This will be followed by potential H₂S treatment modalities that may serve as reprogramming strategies to prevent hypertension and kidney disease of developmental origins. These H₂S treatment modalities include precursors for H₂S synthesis, H₂S donors, and natural plant-derived compounds. Despite emerging evidence from experimental studies in support of reprogramming strate...Continue Reading

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Citations

Jan 24, 2019·Journal of Nephrology·Alessandra F PernaDiego Ingrosso
Nov 26, 2019·Chinese Medical Journal·Yu WangQiong-Jing Yuan
Dec 20, 2019·Chinese Medical Journal·Yu WangQiong-Jing Yuan
Jun 18, 2020·Nutrients·Chien-Ning Hsu, You-Lin Tain
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Apr 14, 2021·Redox Biology·Maurits RoordaHjalmar R Bouma
Jun 1, 2021·Clinical Hemorheology and Microcirculation·Maria FornalTomasz Grodzicki
Aug 28, 2021·Journal of Clinical Medicine·Oscar McCookTamara Merz

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Methods Mentioned

BETA
pharmacotherapies

Software Mentioned

DOHaD

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