Hydrogen sulfide inhibits the growth of Escherichia coli through oxidative damage

The Journal of Microbiology
Liu-Hui FuHua Zhang

Abstract

Many studies have shown that hydrogen sulfide (H2S) is both detrimental and beneficial to animals and plants, whereas its effect on bacteria is not fully understood. Here, we report that H2S, released by sodium hydrosulfide (NaHS), significantly inhibits the growth of Escherichia coli in a dose-dependent manner. Further studies have shown that H2S treatment stimulates the production of reactive oxygen species (ROS) and decreases glutathione (GSH) levels in E. coli, resulting in lipid peroxidation and DNA damage. H2S also inhibits the antioxidative enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) and induces the response of the SoxRS and OxyR regulons in E. coli. Moreover, pretreatment with the antioxidant ascorbic acid (AsA) could effectively prevent H2S-induced toxicity in E. coli. Taken together, our results indicate that H2S exhibits an antibacterial effect on E. coli through oxidative damage and suggest a possible application for H2S in water and food processing.

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Citations

Jun 7, 2020·Applied and Environmental Microbiology·Chulwoo ParkWoojun Park
Sep 8, 2018·Biochemical Society Transactions·Lauren K WarehamRobert K Poole
Aug 28, 2020·Frontiers in Microbiology·Say Yong NgWilfried Moreira
Nov 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milica LazarevićĐorđe Miljković
Feb 1, 2021·Ageing Research Reviews·Alexander S SokolovAlexey A Moskalev
Aug 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nahzli DilekCsaba Szabo
Jun 3, 2021·Antioxidants·Sofia S MendesLígia M Saraiva
Nov 2, 2021·Journal of Applied Microbiology·John T Lisle, George Lukasik

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